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Prospective randomized trial of the effectiveness of clonazepam and diazepam in petit mal status



Prospective randomized trial of the effectiveness of clonazepam and diazepam in petit mal status



Nervenarzt 57(11): 667-671



The effectiveness and tolerance of clonazepam and diazepam were compared in a prospective study on 28 patients. A petit mal status could be broken by clonazepam therapy in 87% of the patients and by diazepam therapy in 85% of the patients. A relapse was seen in 31% of the cases under diazepam and in 20% of the cases under clonazepam. A lower side effect rate was seen with clonazepam than with diazepam. Despite a comparable anti-convulsive effectiveness, the lower side effect rate and the lower relapse rate, as well as lower development of tolerance, made clonazepam the preferred agent in the treatment of petit mal status.

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Accession: 006206108

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