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Prospective study of early rheumatoid arthritis 1. prognostic value of immunoglobulin a rheumatoid factor


Annals of the Rheumatic Diseases 43(5): 673-678
Prospective study of early rheumatoid arthritis 1. prognostic value of immunoglobulin a rheumatoid factor
Patients (33) with early arthritis, 28 of whom developed classical/definite rheumatoid arthritis (RA), were followed up for 2-4 yr. Rheumatoid factor (RF) levels of the IgM, IgA, and IgG isotypes were measured in serum and synovial fluid by an ELISA [enzyme-linked immunosorbent assay] technique developed in our laboratory. All 7 patients who presented with raised IgA RF developed erosions of their hands and wrists. This was significantly different from the remaining 26. None of the 5 patients who presented with isolated elevation of IgM RF developed erosive disease. The patients with raised IgA RF needed significantly more treatment with specific drugs than the remaining 26. The detection of IgA RF in early RA may indicate poor prognosis, justifying a more aggressive treatment at an early stage.


Accession: 006206180



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