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Prospective study on the frequency of respiratory allergens involved in rhinitis and bronchial asthma in the adult

Prospective study on the frequency of respiratory allergens involved in rhinitis and bronchial asthma in the adult

Schweizerische Medizinische Wochenschrift 116(36): 1205-1210

In a prospective study of 100 adults, we determined the frequency of hypersensitivity to allergens most often diagnosed in patients suffering from rhinitis and bronchial asthma. Skin-prick tests and RAST for 15 allergens were performed in all patients. The most frequent allergen detected by skin-prick test was the extract "total house dust" (50%) but the corresponding RAST was rarely positive (16%); then came grass pollen (46%), house dust mites (D. pteronyssinus, 38%) and animal danders (cat 33%). On the other hand, a positive skin test with the two moulds chosen was rare (Alternaria tenuis 5%, Cladosporium herbarum 4%). For all the allergens investigated, the correlation between positive skin test and positive RAST was proportional to the intensity of the skin reaction (94% for the skin tests++++, 40% for the skin test++). 35% of the patients with at least a positive skin test and a RAST for one of the allergens tested had in fact a total IgE concentration not suggestive of atopy (less than 100 kU/l). The results indicate that, with the exception of the 2 moulds chosen, the frequency of allergens diagnosed in Switzerland is very similar to what has been found in other countries with different climates.

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Accession: 006206270

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