Prospects for prenatal diagnosis of cystic fibrosis: induction of biochemical abnormalities in fibroblasts from patients with cystic fibrosis by a urinary glycoprotein

Hösli, P.; Erickson, R.P.; Vogt, E.

Biochemical and Biophysical Research Communications 73(2): 209-216

1976


ISSN/ISBN: 0006-291X
PMID: 999707
DOI: 10.1016/0006-291x(76)90695-1
Accession: 006206363

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Abstract
Alkaline phosphatase activity, assayed on a per cell basis with an ultra micro-method, can be increased up to 7-fold in fibroblast cultures derived from patients with cystic fibrosis by induction with a urinary glycoprotein. Fibroblasts from normal and heterozygous individuals are not significantly induced. There is a suggestion of heterogeneity among cases as reflected in varying baseline alkaline phosphatase and .alpha.-glucosidase levels.