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Prostacyclin and heparin during hemodialysis comparative effects

Life Support Systems 4(3): 205-209

Prostacyclin and heparin during hemodialysis comparative effects

Haemodialysis was performed using heparin (dialysis I: heparin regimen 1, 2000 U/h) in ten patients. These subjects were then given an infusion of prostacyclin, in the form of epoprostenol sodium salt (dialysis II: prostacyclin, 5 ng .cntdot. kg-1 .cntdot. min-1), followed by an infusion of prostacyclin and heparin (dialysis III: heparin regimen 2, 500 U/h). Absolute platelet count, in vitro platelet aggregation and plasma beta-thromboglobulin decreased during prostacyclin infusion. Haemodialysis neutropenia was improved by prostacyclin. The membrane sieving coefficient factor and ultrafiltration volume were not improved by prostacyclin alone (dialysis II). Prostacyclin together with heparin (dialysis III) showed, 60 minutes after the start, an unchanged sieving coefficient factor compared with that of heparin alone, while the ultrafiltration volume significantly (P < 0.001) improved. The results of this study confirm those of earlier studies and suggest that prostaglandin I2 together with low-dose heparin improve the biocompatibilty and efficiency of dialysis treatment.

Accession: 006206504

PMID: 3537544

Related references

Helmling E.; Seyfert U.T.; Albert F.W., 1986: Effects of different antithrombotic agents prostacyclin heparin cg 4203 on platelets and hemostasis during bicarbonate hemodialysis. Thrombosis Research (SUPPL 6): 145

Camici, M.; Evangelisti, L., 1986: Prostacyclin and heparin during haemodialysis: comparative effects. Haemodialysis was performed using heparin (dialysis I: heparin regimen 1, 2000 U/h) in ten patients. These subjects were then given an infusion of prostacyclin, in the form of epoprostenol sodium salt (dialysis II: prostacyclin, 5 ng X kg-1 X min-...

Kuźniewski, M.; Sułowicz, W., 1990: Evaluation of the effectiveness of hemodialysis using only heparin or prostacyclin with heparin. In ten patients treated by maintenance hemodialysis due to end-stage renal failure evaluation of dialysis efficiency was performed during the treatment with heparin alone as well as in the course of prostacyclin -heparin infusion. Statistically si...

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Wessel Aas T.; Berg K.J.; Wideroe T E.; Wirum E.; Nilsen T., 1984: Toxicity of plasma from hemodialysis patients treated with heparin or prostacyclin. Hemodialysis was performed in 6 uremic patients with either a bolus dose of 5000 IU heparin or prostacyclin at a constant infusion rate of 5 ng/kg per min. Clinical data, plasma triglycerides (TG), free fatty acids (FFA), platelet aggregation, whi...

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