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Prostacyclin formation in cancer tissue of the human gastro intestinal tract

Prostacyclin formation in cancer tissue of the human gastro intestinal tract

Wiener Klinische Wochenschrift 93(23): 717-720

Prostacyclin synthesis was studied by means of bioassay in histologically classified biopsy material derived from the human gastrointestinal tract. Tumor tissue generated significantly more prostacyclin than normal tissue. Whether this enhanced PGI2 formation is due to an increased number of endothelial cells in tumor tissue, or represents a characteristic property of the tumor cell itself is not yet clear. This property could be used in future for the detection and control follow-up of malignant disease by means of radioimmunological determination of stabile metabolites as a tumor marker.

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Accession: 006206575

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