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Prostacyclin induced gastric mucosal vaso dilation and inhibition of acid secretion in the dog

Proceedings of the Society for Experimental Biology & Medicine 163(2): 228-232

Prostacyclin induced gastric mucosal vaso dilation and inhibition of acid secretion in the dog

Intraarterial [i.a.] infusion of PG[prostaglandin]I2 [prostacyclin] or PGE2 caused a dose-dependent inhibition of histamine-stimulated gastric acid secretion in an in vivo-chambered stomach, PGI2 being less potent inhibitor than PGE2. While PGE2 decreased gastric mucosal blood flow, PGI2 caused a marked and dose-dependent increase in mucosal blood flow. PGI2 was also secretory inhibitor after i.v., but not after intraportal administration. 6-Keto-PGF1.alpha., a breakdown product of PGI2, had no effect on gastric secretion or gastric mucosal circulation. PGI2 lowered systemic arterial blood pressure, the effect being more pronounced after i.v. than i.a. or portal administration. This suggests a marked inactivation of this PG during the liver transit.

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Accession: 006206600

PMID: 6987676

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