EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Prostaglandin biosynthesis and metabolism in rat brain slices



Prostaglandin biosynthesis and metabolism in rat brain slices



Research Communications in Chemical Pathology and Pharmacology 14(3): 455-469



Prostaglandin F2alpha and E were measured in the slices and in the media after incubation of rat brain slices. About 5 to 10 times more prostaglandin F2alpha than prostaglandin E was found, most of which was secreted into the media. In the absence of oxygen or in the presence of indomethacin, prostaglandin levels in both the slices and media were reduced. Serotonin, norepinephrine, epinephrine, and DOPA, at 10(-3) M concentrations, increased the prostaglandin F2alpha/E ratio in both the media and slices. The levels of prostaglandins F2alpha found in the slices and media when the slices were incubated with prostaglandin E2 increased significantly, this increase being independent of the presence of indomethacin. This suggests that prostaglandin E2 was being converted to F2alpha by a prostaglandin E2 9-ketoreductase in the rat brain slices.

(PDF 0-2 workdays service: $29.90)

Accession: 006206792

Download citation: RISBibTeXText

PMID: 959652



Related references

The effect of prostaglandin F2alpha on arachidonate and lipid-choline metabolism in rat brain slices in vitro. Advances in Prostaglandin and Thromboxane Research 3: 85-88, 1978

Effect of prostaglandin d 2 prostaglandin e 2 and prostaglandin f 2 alpha on catecholamine release from slices of rat and rabbit brain. European Journal of Pharmacology 69(4): 421-428, 1981

Prostaglandin e 2 and prostaglandin f 2 alpha and acetyl cholin esterase activity in the slices of some structures in the cats brain. Archives Internationales de Physiologie et de Biochimie 89(4): 379-384, 1981

Effects of temperature, prostaglandin D-2 and prostaglandin E-2 on neuronal firing rates in preoptic area rat brain slices. Society for Neuroscience Abstracts 20(1-2): 160, 1994

Effects of catecholamines on prostaglandin biosynthesis by dog renal inner medullary slices. Japanese Journal of Pharmacology 32(SUPPL): 273P, 1982

Stimulation of the biosynthesis of prostaglandin e 2 and prostaglandin f 2 alpha in the brain of f 1 cba x c 57bl mice by the tranquilizer phenazepam. Doklady Biochemistry 258(1-6): 141-146, 1981

Metabolism of N-alkyl compounds during the biosynthesis of prostaglandins. N-Dealkylation during prostaglandin biosynthesis. Molecular Pharmacology 21(1): 133-141, 1982

Effect of prostaglandin e 2 on the capillary system of the brain during sympathetic nerve stimulation and inhibition of prostaglandin biosynthesis. Krovoobrashchenie 14(6): 3-7, 1981

Effects of divalent cations on prostaglandin biosynthesis in rabbit kidney medulla slices. Israel Journal of Medical Sciences 15(1): 72, 1979

Effects of divalent cations on prostaglandin biosynthesis and phospholipase A2 activation in rabbit kidney medulla slices. Advances in Prostaglandin and Thromboxane Research 6: 231-234, 1980

Effects of bivalent cations of prostaglandin biosynthesis and phospho lipase a 2 activation in rabbit kidney medulla slices. Biochemical Journal 182(3): 821-826, 1979

Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat. Journal of Neurotrauma 19(9): 1051-1064, 2002

Changes of enzymes involved in prostaglandin metabolism and prostaglandin binding proteins in rat brain during development and aging. Journal of Neurochemistry 45(2): 483-489, 1985

Iodine metabolism in thyroid slices: effects of TSH, dibutyryl cyclic 3',5'-AMP, NaF and prostaglandin E-1. Endocrinology 86(2): 396-405, 1970