+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Prostaglandin d 2 potentiates cholinergic responsiveness in guinea pig trachea

Journal of Autonomic Pharmacology 6(3): 181-186
Prostaglandin d 2 potentiates cholinergic responsiveness in guinea pig trachea
1 PGD2 dose dependently potentiated the parasympathetic-induced contraction in guinea-pig trachea in vitro. This phenomenon was much more evident in ovalbumin-sensitized guinea-pig trachea. 2 Indomethacin pretreatment enhanced the capacity of PGD2 to potentiate cholinergic-induced contraction in normal but not in ovalbumin-sensitized guinea-pig. 3 PGD2 shifted to the left the curve of the exogenous acetylcholine-induced contraction in guinea-pig trachea, indicating a postsynatptic site of action of PGD2. 4 These data suggest a role of PGD2 in the genesis of hyperreactivity of tracheal smooth muscles, particularly in a model of pulmonary anaphylaxis.

(PDF 0-2 workdays service: $29.90)

Accession: 006206872

Related references

Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea. Journal of Autonomic Pharmacology 6(3): 181-186, 1986

Inflammatory mediator interactions prostaglandin d 2 potentiates histamine and cholinergic responsiveness. American Review of Respiratory Disease 131(4 SUPPL): A29, 1985

Sensory nerve depletion potentiates non-adrenergic, non-cholinergic inhibitory nerves in guinea-pig trachea. British Journal of Pharmacology 98 Suppl: 780p-780p, 1989

Role for arginase in the regulation of cholinergic airway responsiveness and cNOS activity in guinea pig trachea. Nitric Oxide 4(3): 246, 2000

Evidence that the histamine sensitivity and responsiveness of guinea-pig isolated trachea are modulated by epithelial prostaglandin E2 production. British Journal of Pharmacology 95(1): 300-308, 1988

Somatostatin potentiates cholinergic neurotransmission in ferret trachea. Journal of Applied Physiology 67(6): 2397-2400, 1989

Pharmacological study of prostaglandin 24 difference in the responsiveness to prostaglandin e 2 and prostaglandin f 2 alpha of isolated gastro intestinal tract in rat hamster and guinea pig. 1981

Effects of prostaglandin e 1 prostaglandin e 2 and prostaglandin f 2 alpha on the activity of muscle strips isolated from guinea pig stomach interaction with cholinergic and adrenergic receptors. Acta Physiologica et Pharmacologica Bulgarica 8(3): 24-25, 1982

Effect of mixture of prostaglandin e 1 and prostaglandin f 2 alpha on the guinea pig trachea. Samuelsson, Bengt And Rodolfo Paoletti (Ed ) Advances in Prostaglandin And Thromboxane Research, Vol 2 Proceedings Of International Conference Florence, Italy May 1975 Xvi+522p Illus Raven Press: New York, N Y , U S A Isbn 0-89004-050-8 962, 1976

Histamine potentiates parasympathetic neural contractions in canine trachea by increasing inherent responsiveness of airway smooth muscle. American Review of Respiratory Disease 127(4 PART 2): 66, 1983