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Prostaglandins and congeners part 21 synthesis of some cyclo hexyl analogs 11a homo prostaglandins



Prostaglandins and congeners part 21 synthesis of some cyclo hexyl analogs 11a homo prostaglandins



Journal of Organic Chemistry 44(1): 71-75



Several 6-membered ring analogs of prostaglandin [PG] E1 were prepared. The compounds were all synthesized via conjugate addition of organometallic reagents to cyclohexenone. A cyclohexenone analog of PGA1 was prepared by a high-yield multistep net dehydrogenation of a cyclohexanone precursor. The PGA1 analog [9-oxo-15-hydroxy-11a-homo-10,13-trans-prostadienoic acid] was partially hydrated to the PGE1 analog [9-oxo-11a,15-dihydroxy-11a-homo-13-trans-prostenoic acid] in aqueous base.

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Accession: 006207855

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