Protective effects of 2 aminoethylisothiuronium bromide hydrobromide cysteamine hydrochloride and 5 hydroxytryptamine in x irradiated pregnant porton mice
Mazur, L.
Folia Biologica 32(1-2): 81-88
1984
ISSN/ISBN: 0015-5500 Accession: 006210238
Porton mice were either whole-body-X-irradiated with a dose of 500 R or, 15 min before X-irradiation, injected with radioprotectors AET, MEA, or 5-HT [serotonin] in a dose of 40 mg/kg of body weight, on the 1st day of pregnancy. Uterine contents were examined on the 9th day of gestation. As compared with controls, in X-irradiated mice a smaller number of live fetuses and greater numbers of non-implanted embryos and resportions were found. Not all X-irradiated females had live fetuses. AET, MEA and 5-HT when injected to mice before their X-irradiation acted as radioprotectors. The strongest radioprotective effect was obtained following AET administration, intermediate after 5-HT treatment, and the weakest when MEA was injected.