EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Proto oncogene expression and cloned t lymphocytes mitogens and growth factors induce different patterns of expression



Proto oncogene expression and cloned t lymphocytes mitogens and growth factors induce different patterns of expression



Oncogene 1(2): 223-228



We have compared the effects of a mitogenic lectin, concanavalin A (Con A), and a growth factor, interleukin-2 (IL-2), on the expression of the c-myc, c-fos, and c-myb proto-oncogenesis in cloned T lymphocytes. Accumulation of c-myc mRNA was induced by both ConA and IL-2 in these cells. In contrast, expression of c-fos was stimulated primarily by ConA, and accumulation of c-myb mRNA was induced predominantly by IL-2. Thus, ConA and IL-2 induce expression of overlapping, but non-identical, sets of proto-oncogenes in T lymphocytes. Investigations with several different cloned T cells revealed that: (1) c-myb is not induced in all T cells stimulated to grow, indicating that its expression may not be absolutely required for their proliferation; and (2) expression of c-myc, seen in combination with c-fos, can be sufficient for growth, demonstrating functional differences between cellular and viral oncogenes in T cells. These observations provide insight into the roles of the c-myc, c-fos, and c-myb proto-oncogenes in normal T cell responses.

(PDF 0-2 workdays service: $29.90)

Accession: 006215241

Download citation: RISBibTeXText

PMID: 3501855



Related references

Kinetics of cellular oncogene expression in mouse lymphocytes i. expression of c myc and c ras h a in t lymphocytes i. expression of c myc and c ras h a in t lymphocytes induced by various mitogens. European Journal of Immunology 16(3): 312-316, 1986

Overexpression of the c myc proto oncogene can induce apoptosis that is inhibited by expression of the bcl 2 proto oncogene. FASEB Journal 6(5): A1619, 1992

Kinetics of cellular oncogene expression in mouse lymphocytes. I. Expression of c-myc and c-ras-Ha in T lymphocytes induced by various mitogens. European Journal of Immunology 16(3): 312-316, 1986

Regulation of cytochrome P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes. Febs Letters 273(1-2): 219-222, 1990

Proto-oncogene expression and growth factors during liver regeneration. Symposium on Fundamental Cancer Research 39: 69-86, 1986

Expression of src proto oncogene and insulin like growth factors in breast tumors. Laboratory Investigation 58(1): 82A, 1988

Transcriptional regulation of proto oncogene expression by serum growth factors. Proceedings of the American Association for Cancer Research Annual Meeting 31: 511, 1990

Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors. In Vitro Cellular & Developmental Biology 24(2): 81-84, 1988

Estrogen induction of insulin-like growth factors and myc proto-oncogene expression in the uterus. Journal of Steroid Biochemistry and Molecular Biology 40(1-3): 223-230, 1991

Spatial temporal patterns of c fos proto oncogene and type i collagen gene expression during compensatory lung growth. American Review of Respiratory Disease 143(4 PART 2): A520, 1991

Evidence for a common program of proto oncogene expression induced by diverse growth factors. Gluzman, Y (Ed ) Current Communications in Molecular Biology: Eukaryotic Transcription: The Role Of Cis- And Trans-Acting Elements in Initiation; 2nd Conference on Eukaryotic Transcription, Cold Spring Harbor, N Y , Usa, Mar 24-27, X+200p Cold Spring Harbor Laboratory: Cold Spring Harbor, N Y , Usa Illus Paper 161-165, 1985

Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type b transforming growth factor. The Journal of Biological Chemistry 265: 56-62, 1990

Regulation of bovine bronchial epithelial cell proliferation and proto-oncogene expression by growth factors. American Journal of Respiratory Cell and Molecular Biology 5(6): 548-555, 1991

N-myc proto-oncogene expression can induce DNA replication in Balb/c 3T3 fibroblasts. Oncogene 2(3): 289-291, 1988