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Proton hypophysectomy and induction of mammary gland carcinoma



Proton hypophysectomy and induction of mammary gland carcinoma



Meditsinskaya Radiologiya 24(2): 53-57



Irrespective of the size of the damaged part of the hypophysis after single irradiation with a narrow beam of protons [doses of 15,000-30,000] tumors of the mammary gland did not develop in hypophysectomized rats, whereas in the control group they appeared in 81% of the animals. There were slight variations in the mass index of the ovaries, adrenals and the uterus in animals with partial or complete damage of the hypophysis. The clinical effect of hypophysectomy may be determined not only by the complete damage of the hypophysial tissue. Selective exclusion of certain structures of the hypophysis may pertain to regulation of the mammary gland proliferative and functional activity by means of bloodless destruction.

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