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Pulmonary function effects of 1.0 and 2.0 parts per million sulfur dioxide exposure in active young male nonsmokers



Pulmonary function effects of 1.0 and 2.0 parts per million sulfur dioxide exposure in active young male nonsmokers



Journal of the Air Pollution Control Association 34(11): 1117-1121



The threshold concentration of SO2 which will induce pulmonary function changes in the normal population has not been established. To investigate this question, 9 young healthy adult nonsmoking males were exposed for 2 h to filtered air (FA), 1.0 ppm SO2 and 2.0 ppm SO2. In a follow-up study an additional 14 subjects were exposed to FA and 1.0 ppm SO2 conditions. Forced expiratory tests were performed prior to and following the 2 h exposure, and 5 min after each of three 30 min exercise periods. The work load during the exercise periods was set to elicit a minute ventilation of 40 l BTPS [body temperature, ambient pressure, saturated]. Thoracic gas volume (TGV), airway resistance (Raw), maximal voluntary ventilation (MVV) and He dilution functional residual capacity (FRC) were also measured before and after the exposure. In the initial subject group (9), none of the spirometric tests demonstrated any significant effects to the subject from exposure to 1.0 or 2.0 ppm SO2 after 30 min of continuous exercise or 2 h of intermittent exercise. The only significant change (P < 0.05) was an increase in specific airway resistance (SRaw) following exposure to 1.0 or 2.0 ppm SO2. When this observation was studied in the larger (23) subject group exposed to 1.0 ppm SO2, neither SRaw nor any of the other pulmonary function tests indicated a significant effect of exposure to 1.0 ppm SO2.

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Accession: 006222909

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