Section 7
Chapter 6,249

Radiation biological investigations with multi cellular spheroids as an in vitro tumor model part 2 cell contact modeled by small multi cellular spheroids enhances cell survival and dna single strand break rejoining

Korner, I.J.; Kopp, J.; Malz, W.

Studia Biophysica 68(2): 161-162


Accession: 006248732

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Monolayers and multicellular spheroids of cultured Chinese hamster lung cancer V-79-4 cells were tested for their ability to survive ionizing radiation. Comparison of survival curves indicated a definite increase in radioresistance for the small spheroids. Using alkaline sucrose gradient sedimentation, DNA strand breakage repair was studied as a possible mechanism of survival. Single cells showed slower and less complete repair than cells in spheroids.

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