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Radiosensitization by cisplatin of rif 1 tumor cells in vitro


, : Radiosensitization by cisplatin of rif 1 tumor cells in vitro. International Journal of Radiation Biology & Related Studies in Physics Chemistry & Medicine 50(5): 871-884

The ability of cis-diamminedichoroplatinum(II) (c-DDP) to enhance radiation-induced cell killing was tested on oxic RIF1 tumour cells in monolayer culture. Marked radiosensitization of the survivors of a 1 h drug treatment was found with all c-DDP doses treated, with enhancement ratios increasing from 1.2 to 2.2 with increasing drug dose. Isobologram analyses showed that the interaction of c-DDP with X-rays were supra-additive. To test whether part of the enhancement was due to a selection of subpopulations, the diploid and tetraploid RIF1 cells, which normally coexist in culture, were separated by (a) unit gravity velocity sedimentation, and (b) by developing diploid and tetraploid clones. Both methods showed that there was little difference in either drug sensitivity or radiation sensitivity between diploid and tetraploid cells. DNA histograms obtained by flow cytometry showed little or no cycle progression during the 1 h drug treatment. These data indicate that the radiosensitization was not the result of the drug exposure leaving cells in a radiosensitive phase. The observed radiosensitization, therefore, appears to have resulted from a true drug/X-ray interaction.

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Puckett C.L.; Shingleton W.W., 1972: The effect of induced diabetes on experimental tumor growth in mice. Cancer Research 32(4): 789-790

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Vlasenko, Vm; Burdeniuk, Af, 1984: Amputation of chick wings with laser beams. Visnyk sil's'kohospodars'koi nauky: (11) 65

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Osorio, M. E.; Salazar, E.; Zambrano, A. Y.; Demey, J. R., 2003: Genetic diversity of a cocoa collection by means of RAPD. Genetic diversity was evaluated by random amplified polymorphic DNA in criollo cocoa materials belonging to the germplasm collection 95 in Ocumare de la Costa, Aragua State, Venezuela. The materials were classified into 3 reference cocoa groups: c...

Roustan, P.; Curtis, A. R. J.; Kamakari, S.; Thiselton, D.; Lindsay, S.; Bhattacharya, S. S., 1992: Dinucleotide repeat polymorphism at the DXS559 locus. Human Molecular Genetics 1(9): 778

Coleman, Hedley; Kennedy, Mark; Altini, Mario; Crooks, Jean; Tsakiris, Peter, 1996: Neuroendocrine (carcinoid) tumor of the mandible: A case report and review of the literature. The aim of this article is to present a case of primary neuroendocrine tumor (typical carcinoid) of the mandible that occurred in a 46-year-old black woman who was seropositive for the human immunodeficiency virus. Radiologically the lesion presen...

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