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Radiosensitizing and cytotoxic effects of hyperthermia on various biological systems radiosensitizing and cytotoxic effects on hyperthermia on mouse hemopoietic stem cells


Radiobiologiya 24(3): 325-329
Radiosensitizing and cytotoxic effects of hyperthermia on various biological systems radiosensitizing and cytotoxic effects on hyperthermia on mouse hemopoietic stem cells
Dose dependences of heat-induced inactivation of CFU [colony forming units] were described for the temperature range of 41-44.degree. C. The energy of activation of the processes of thermal death was 100-120 kcal/M. CFU were more resistant to heating than the cells of mouse leukemia. Heating 1 h or immediately before irradiation had a radiosensitizing effect on CFU. When bone marrow cells were heated 1 h after irradiation the radiosensitizing effect was absent: there was only a simple summation of the effects of the 2 damaging agents.


Accession: 006255121



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