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Radiosensitizing and cytotoxic properties of misonidazole on glutathione synthetase deficient human fibroblasts


International Journal of Radiation Biology & Related Studies in Physics Chemistry & Medicine 48(2): 213-222
Radiosensitizing and cytotoxic properties of misonidazole on glutathione synthetase deficient human fibroblasts
The cytotoxic and radiosensitizing effects of misonidazole were studied on glutathione synthetase deficient fibroblasts and on their controls. At any concentration from 0.1 to 4 mM, deficient cells are more sensitive to the cytotoxic effect of misonidazole than the control cells. The differential effect between the 2 cell strains concerns both the shoulder and the slope of the survival curve, thus suggesting that NPSH play a role in the determination of misonidazole cytotoxicity. Like O2, misonidazole clearly sensitizes deficient cells to a lesser extent than control cells. For both cell strains, the maximum sensitizing effect of misonidazole is very close to that of O2 (1.5 and 1.5 for deficient cells, 2.8 and 2.9 for control cells, respectively). The sensitizing effect of misonidazole appears in the same concentration range for both cell strains, with a maximal effect at lower concentrations for deficient cells.

Accession: 006255122

PMID: 3874843

DOI: 10.1080/09553008514551211

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