EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Radiotherapy for the treatment of pulmonary complications of paraquat poisoning


Human Toxicology 7(4): 325-332
Radiotherapy for the treatment of pulmonary complications of paraquat poisoning
The effect of radiotherapy on the pulmonary damage caused by paraquat (24% solution of 1,1'-dimethyl-4,4'-bipyridylium dichloride) was investigated in a preliminary series of nine patients. Paraquat intoxication was diagnosed by quantitative analysis of urine and plasma using colorimetry after extraction of a cation exchange column. The irradiation was given as a planned procedure from day 2 in cases 1 to 7, and after changes in chest X-ray were recognized in cases 8 and 9. A cobalt-60 unit with opposed anterior and posterior portals was used to give a total dose of 12,50 Gy (uncorrected) over 10 fractions, sparing the pericardium and mediastinum as much as possible. Each fraction consisted of 1.25 Gy (125 rad) given once a day, alternating between the left and right lungs. Radiological diagnosis consisted of clear chest X-rays (cases 2 to 4), pulmonary oedema (cases 7 and 9) and interstitial infiltrates (cases 1, 5, 6 and 8). Cases 1, 5, and 8 survived. Case 8 had residual interstitial infiltrates three months after ingestion but these had cleared one month later, suggesting that the diagnosis of irreversible fibrosis should only be made after a follow-up period of at least one year. The results have failed to show a definite benefit, but do support the fact that radiotherapy should be assessed carefully in a randomized trial which is now in progress.

(PDF same-day service: $19.90)

Accession: 006255193

PMID: 3044980

DOI: 10.1177/096032718800700405



Related references

Resolution after radiotherapy of severe pulmonary damage due to paraquat poisoning. British Medical Journal 288(6426): 1259-1260, 1984

Acute interstitial pulmonary fibrosis in a patient with paraquat poisoning clinical anatomical observation of a case of paraquat poisoning which had a fatal outcome. Muenchener Medizinische Wochenschrift6: 944-949, 1969

Early radiotherapy in the treatment of paraquat poisoning. British Journal of Radiology 61(725): 405-408, 1988

The prevention and therapeutics effect of sodium bicarbonate with gastric lavage, atomization inhalation and intravenous injection on the patients with paraquat poisoning and pulmonary fibrosis induced by paraquat poisoning. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 33(9): 693-694, 2016

Low-dose radiotherapy of pulmonary complications resulting from paraquat intoxication: report of a case. Taiwan Yi Xue Hui Za Zhi. Journal of the Formosan Medical Association 86(4): 452-455, 1987

Effective treatment for paraquat poisoning in rats and its relevance to treatment of paraquat poisoning in man. British Medical Journal 4(5944): 569-571, 1974

Failure of chemotherapy and radiotherapy in the treatment of paraquat pulmonary fibrosis. Annales Francaises d'Anesthesie et de Reanimation 7(2): 159-161, 1988

Paraquat poisoning. Survival without pulmonary insufficiency after early bleomycin treatment. Acta Pharmacologica et Toxicologica 41 Suppl 2: 246-248, 1977

Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients. Clinical Toxicology 46(6): 515-518, 2008

A case report of successful treatment of severe acute paraquat poisoning with pulmonary aspergillus infection. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29(7): 543-544, 2012