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Radium 226 induced bone cancers effects of delayed sodium alginate treatment

, : Radium 226 induced bone cancers effects of delayed sodium alginate treatment. International Journal of Radiation Biology & Related Studies in Physics Chemistry & Medicine 43(3): 231-248

At the present time no unequivocal evidence exists which shows that a reduction in the body-burden of a radionuclide by decorporative treatment results in a proportional decrease in the risk of long-term radiation effects. The effectiveness was investigated of the daily administration of Na-alginate via the diet in removing 226Ra from the skeleton and in reducing the number of late effects such as osteosarcomas. The animals used were male C57Bl mice which had been injected with 1 of 3 different amounts of 226Ra (4.4, 10.7 or 24.8 kBq [becquerels]) 4 days prior to the onset of the decorporative treatment. Although this treatment was able to produce a substantial reduction in the 226Ra content of the mice it did not reduce the incidence of osteosarcoma. These results question the effectiveness of decorporation procedures initiated at longer times after contamination.

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