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Raised titers of anti klebsiella iga in ankylosing spondylitis rheumatoid arthritis and inflammatory bowel disease

, : Raised titers of anti klebsiella iga in ankylosing spondylitis rheumatoid arthritis and inflammatory bowel disease. British Medical Journal 296(6634): 1432-1434

Serum titres of IgA are raised in ankylosing spondylitis and increased titres of antibodies to klebsiella have also been reported. The humoral response was investigated in ankylosing spondylitis and other inflammatory disorders. IgG antibodies to klebsiella pneumoniae K43 were measured in patients with ankylosing spondylitis, Crohn's disease, ulcerative colitis, and rheumatoid arthritis and in controls. Significantly raised median titres of anti-klebsiella IgA, measured as optical density at 405 nm with an enzyme linked immunosorbent assay (ELISA), were seen among the patients with ankylosing spondylitis (0.7), Crohn's disease (0.8), rheumatoid arthritis (0.6), and ulcerative colitis (0.8) compared with controls (0.4). Activity of disease in ankylosing spondylitis and titres of anti-klebsiella IgA were not correlated. In contrast, titres of anti-klebsiella IgM were significantly lower in patients with ankylosing spondylitis and ulcerative colitis. The increase in the titres of anti-klebsiella IgA may be due to increased permeability of the gut to bacterial antigens, leading to an increased IgA response in the gut mucosa and permitting the release of IgA into the circulation. As the increased antibody titres were seen in Crohn's disease and rheumatoid arthritis as well as in ankylosing spondylitis the response may be non-specific, occurring because of possible underlying inflammatory bowel disease in these conditions.

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Brooks, D. S.; Cassone, V. M., 2000: The distribution of 2 iodomelatonin binding during the development of the chick visual system. FASEB Journal 14(4): A72, March 15

Prado F.E.; Sampietro A.R.; Vattuone M.A., 1979: Ammonium hepta molybdate an inhibitor of plant invertases. Ammonium heptamolybdate was an inhibitor of plant invertases. The inhibition was a linear mixed type and the constants Ki and aKi [dissociation constants] were determined. The inhibition was suppressed by .alpha.- and .beta.-glycerophosphate, 2,3-...

Bulley N.R.; Lee K.W., 1987: Effects of management on the nitrogen content of poultry manure. A comparison was made of the nitrogen and mositure contents of manure collected from three deep-pit poultry barns. One barn had dropping boards with a well-ventilated manure pit. The second unit had air-circulating fans at manure level and the thi...

Foster C.; Schmidt D.H.; Carpenter J.G., 1982: Determinants of left ventricular ejection fraction response to exercise in healthy subjects. Clinical Research 30(2): 186A

Warmington, S. A.; Tolan, R.; Mcbennett, S., 2000: Functional and histological characteristics of skeletal muscle and the effects of leptin in the genetically obese (ob/ob) mouse. BACKGROUND: Skeletal muscle mass in genetically obese (ob/ob) mice displays a reduced mass compared with their normal lean counterpart mice. However, the functional capacity of the available skeletal muscle mass in these animals has not yet been d...

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Hoshino H.; Tanooka H., 1972: Beta ray induced skin tumor induction in mice preliminary results to obtain dose response relation and summation with 4 nitro quinoline effect. Journal of Radiation Research 13(1): 43-44

Middleton R. G., 1973: The Laurence L. Smith Museum; an introduction. Geologic Notes - South Carolina Geological Survey 17(2): 32-48

Michl, Uwe; Graefen, Markus; Haese, Alexander; Hammerer, Peter; Noldus, Jochen; Huland, Hartwig, 2000: Prospective analysis of continence and micturation following nerve sparing and non nerve sparing radical retropubic prostatectomy Significant impact of the nerve sparing procedure on continence. European Urology 37(Suppl 2): 68, March

Camero, Sergio; Ayuso, Jose M.; Barrantes, Alejandro; Benítez, María J.; Jiménez, Juan S., 2013: Specific binding of DNA to aggregated forms of Alzheimers disease amyloid peptides. Anomalous protein aggregation is closely associated to age-related mental illness. Extraneuronal plaques, mainly composed of aggregated amyloid peptides, are considered as hallmarks of Alzheimer's disease. According to the amyloid cascade hyp...