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Rapid determination of paracetamol in plasma by reversed phase high performance liquid chromatography



Rapid determination of paracetamol in plasma by reversed phase high performance liquid chromatography



Journal of Chromatography 173(1): 198-201



The high performance liquid chromatography method described permits the rapid determination of paracetamol in plasma down to 0.2 .mu.g/ml. The preparation of plasma samples prior to chromatography is simple as only a single-step extraction is required. No derivatization procedure is necessary. Both the sensitivity and precision of the method are good and no interfering peaks are seen in plasma. Only a small sample size is needed for analysis, and therefore this method is suitable for routine clinical monitoring of plasma levels in patients and for use in research studies involving pharmacokinetics and bioavailability.

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Accession: 006257925

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PMID: 546873



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