EurekaMag.com logo
+ Translate

Recent data on side effects of beta adrenergic blocking drugs


, : Recent data on side effects of beta adrenergic blocking drugs. Therapie (London/Paris) 40(6): 423-428

Statistical data on untoward side effects of beta-blockers were compiled from either controlled trials on secondary prevention using these drugs or pharmacovigilance studies. Compared to placebo, significant increases in the occurrence of bradycardia, hypotension, peripheral vascular phenomena, asthenia, and bronchospasm were all observed. Antinuclear antibodies and fibrosis (peritoneal, retroperitoneal, and pulmonary) were rarely observed during treatment with beta antagonists and their exact causes unknown. The actual role of beta-blockers in the genesis of fibrosis is uncertain. Different studies on the effects of these drugs on vigilance gave conflicting results. As for sleep disorders, liposolubility and instrinsic sympathomimetic activity seem to be favorizing factors. Sotalol can in some instances favorize torsade de pointes. No objective arguments exist in support of the responsibility of beta antagonists in gastrointestinal problems. In all this study shows that when their contraindications are respected, beta-blockers have a high benefit-to-risk ratio.

(PDF 0-2 workdays service)

Accession: 006269377

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Helgeland, A.; Hjermann, I.; Leren, P.; Holme, I., 1978: Possible metabolic side effects of beta-adrenergic blocking drugs. British Medical Journal 1(6116): 828-828

Beumer, H.M.; Hardonk, H.J., 1972: Side-effects of beta-adrenergic blocking drugs in asthmatics. Indian Heart Journal 24: Suppl 1:226-30

Dany, F.; Bordes, M.M.; Dallocchio, M.; Albin, H.; Dangoumau, J.; Merle, L.; Charmes, J.P.; Brosset, P., 1980: Side effects of beta adrenergic blocking drugs -- a methodological problem. Therapie 35(3): 381-389

Cheymol, G.; Biour, M., 1985: Recent data on the side effects of beta-adrenergic inhibitors. Therapie 40(6): 423-428

Duggan, M.A.; Court, J.B., 1981: A proposed mechanism of production of the autoimmune and lymphoproliferative side-effects of beta-adrenergic-site-blocking drugs and hydantoin anticonvulsants. Annals of Clinical Research 13(6): 406-418

Wilson W.R., 1968: Beta adrenergic receptor blocking drugs in the treatment of cardiac arrhythmias human propranolol cardio vasc side effects. Medical Clinics Of North America: 1017-1029

Wong K.K.; Schreiber E.C., 1972: Recent developments in beta adrenergic blocking drugs. Drug Metabolism Reviews 1(1): 101-116

Augustyniak, M.; Litwin, J., 1967: Blocking of hypotensive effects of histamine by the drugs blocking beta-adrenergic receptors. All the drugs [dichloro-isoproterenol, Indeval, Alderlin] exhibited marked antihistaminic activity in the perfused hind leg of the dog. The possible mechanism of this activity is discussed.

Patil, P.N.; Tye, A.; LaPidus, J.B., 1967: Steric aspects of adrenergic drugs. V. Beta adrenergic blocking effects of optical isomers of methoxamine and isopropylmethoxamine. Journal of Pharmacology and Experimental Therapeutics 156(3): 445-451

Frishman, W., 1980: Clinical pharmacology of the new beta-adrenergic blocking drugs. Part 13. The beta-adrenoceptor blocking drugs: a perspective. American Heart Journal 99(5): 665-670