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Recent developments in carbon 13 nmr and proton nmr


, : Recent developments in carbon 13 nmr and proton nmr. Journal of Natural Products (Lloydia) 47(2): 226-259

The fundamentals of pulsed Fourier transform NMR and nuclear spin dynamics are reviewed as a basis for explaining several recently developed experiments: APT (Attached Proton Test), INEPT [Intensive Nuclei Enhanced by Polarization Transfer], carbon-carbon connectivity, and a number of 2-dimensional versions of these basic pulse sequences. The general procedures for applying these experiments are outlined and examples of the results are given. The direct evidence of chemical bonding provided by these methods offers a more reliable procedure for structural determinations than traditional inferential methods based on spectral interpretation. Application of these techniques to natural product structure elucidation is illustrated by several examples [Hepialus californicus pheromone, insect growth inhibitor from marine algae, 5.alpha.-androstane.].

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Related references

Angelotti, T.; Krisko, M.; O'connor, T.; Serianni, A.S., 1987: 1 carbon 13 aldono 1 4 lactones conformational studies based on proton proton carbon 13 proton and carbon 13 carbon 13 spin couplings and ab initio molecular orbital calculations. Several aldono-1,4-lactones have been synthesized with [13C] enrichment (99 atom %) at the carbonyl carbon. 1H (300 and 600 MHz) and 13C (75 MHz) NMR spectra in 2H2O have been assigned, the latter with the aid of 2D 13C-1H chemical shift correlati...

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