Section 7
Chapter 6,275

Recovery of spontaneous alternation following lesions of the entorhinal cortex in adult rats: possible correlation to axon sprouting

Scheff, S.W.; Cotman, C.W.

Behavioral Biology 21(2): 286-293


ISSN/ISBN: 0091-6773
PMID: 911288
DOI: 10.1016/s0091-6773(77)90374-1
Accession: 006274669

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Adult rats with unilateral or bilateral lesions of the entorhinal cortex were tested over time for changes in spontaneous alternation behavior. Rats with bilateral lesions did not display spontaneous alternation throughout the duration of the study. This suggests that the entorhinal area plays an important role in the manifestation of spontaneous alternation. In contrast to rats with bilateral lesions, those with unilateral lesions displayed recovery to preoperative levels of alternation within 10 days after surgery. The circuitry changes accompanying axon sprouting after unilateral lesions may participate in the recovery of spontaneous alternation.

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