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Reduction of residual toluene content in beta cyclo dextrin through preparing inclusion complexes



Reduction of residual toluene content in beta cyclo dextrin through preparing inclusion complexes



Starch 35(9): 320-322



.beta.-Cyclodextrin, which is used mainly for inclusion complexation of flavors or drugs, may contain traces of organic solvent if solvent was applied during enzymic conversion to facilitate the separation and to improve the yield of the product. Maximum 10 ppm is the tolerated toluene content, but, generally no more than 3 ppm was found in a series of batches. .beta.-Cyclodextrin samples were prepared with 10, 20 and 100 ppm 3H-labeled toluene inclusion, and from these artificially contaminated samples drug or flavor complexes were prepared. The complex preparation process reduced the toluene content of 9-62% of that of the starting level. Assuming that 2 ppm toluene is the residual contamination in the complex, 1 g .beta.-cyclodextrin/day consumption means an accumulated intake of 22 mg toluene in 30 years.

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