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Regulation of expression of a human lymphoid cell surface marker by iron

Regulation of expression of a human lymphoid cell surface marker by iron

Cellular Immunology 53(1): 71-83

ISSN/ISBN: 0008-8749

PMID: 7407934

DOI: 10.1016/0008-8749(80)90427-x

Spontaneous rosette formation of human peripheral blood lymphocytes with sheep erythrocytes was inhibited by pretreatment of cells with iron citrate, fully saturated TF [transferrin] (but not native TF), fully saturated LF [lactoferrin] or native LF. The inhibition was observed within 5 min of incubation; it was relatively temperature-dependent and not mediated by the presence of macrophages, since it occurred after depletion of adherent cells from the suspension. The inhibitory effect of Fe was reversed by further treatment of the cells with 2 highly specific Fe chelating agents, DFX [desferrioxamine] and SHAM [salicylhydroxamic acid], or culture in medium supplemented with 15% FCS [fetal calf serum]. Alternate expression or inhibition of the receptor was observed when the cells were cultured sequentially in low- or high-Fe medium for periods of 24 h. Apparently, this is the 1st demonstration of regulation of expression of a surface marker in mammalian cells by Fe. Fe is known to play a similar regulatory role of membrane receptors in bacteria.

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Accession: 006287758

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