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Regulation of genetic activity with thyroid hormones 2. interaction specificity of thyroxine cytoplasmic receptors isolated from human embryo fibroblasts and hela cells with dna

, : Regulation of genetic activity with thyroid hormones 2. interaction specificity of thyroxine cytoplasmic receptors isolated from human embryo fibroblasts and hela cells with dna. Problemy Endokria 27(2): 66-70

A new approach is presented for evaluating the receptor and hormone-receptor complex specific interaction with DNA and revealing the cause of the absence of the hormone-receptor complex acception with HeLa cell chromosomes. Hormone-receptor complexing should precede specific interaction with DNA. The purified receptor-thyroxine complex is saturatable and specifically competes with Hae III restrictase, protecting specific sites of DNA recognition from this enzyme. Specificity of the hormone-receptor complex interaction with DNA depends on the sequences surrounding Hae III restriction site. The HeLa cell hormone-receptor complex does not interact with the recognition site for the normal hormone-receptor complex.

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