+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of glomerular capillary pressure and filtration rate in young Kyoto hypertensive rats

Clinical Science 56(3): 203-209

Regulation of glomerular capillary pressure and filtration rate in young Kyoto hypertensive rats

Single nephron pressures, flows and resistances were studied in 17-18 wk old genetically hypertensive and normotensive Kyoto rats resembling one another in renal weight, total filtration rate, morphology and glomeruli number in the kidney. Glomerular capillary pressures were similar in the 2 groups; the hypertensive rats had lower pressures at the end of the efferent arteriole than did the normotensive animals. Nephron filtration rates were similar in both groups. At the same time, the hypertensive rats had higher nephron filtration fractions, and their glomerular blood flow was lower than that of the normotensive rats. These changes in the hypertensive animals were due to their higher afferent and efferent arteriolar resistances. Despite their high blood pressure, the glomerular ultrafiltration forces in hypertensive rats were almost identical with those in normotensive rats. The regulation of glomerular capillary pressure and filtration rate in young Kyoto hypertensive rats is due to a balance of afferent-efferent arteriolar tonus. The normal glomerular capillary pressures and low efferent arteriolar pressures of these animals are most likely the functional basis for the lack of structural changes at these sites. Apparently the Kyoto animal's renal response to hypertension resembles that of most essential hypertensive patients, both in function and morphology.

Accession: 006288030

PMID: 477202

DOI: 10.1042/cs0560203

Related references

Ploth, D.W.; Dahlheim, H.; Schmidmeier, E.; Hermle, M.; Schnermann, J., 1978: Tubuloglomerular feedback and autoregulation of glomerular filtration rate in Wistar-Kyoto spontaneously hypertensive rats. Pflugers Archiv 375(3): 261-267

Stier C.T.Jr; Dilley J.R.; Arendshorst W.J., 1982: Tubulo glomerular feedback in young spontaneously hypertensive rats with reduced glomerular filtration rate. Kidney International 21(1): 248

Wiebelhaus V.D.; Sosnowski G.F.; Mann W.; Sulat L.; Brennan F., 1977: Glomerular filtration rate renal plasma flow and sodium excretion in normal wistar kyoto and spontaneously hypertensive rats. Kidney International 12(6): 578

Kuczyńska-Sicińska, J., 1972: Effect of angiotensin II on arterial blood pressure, glomerular filtration rate and urinary sodium excretion in normal, pregnant and hypertensive rats. Polish Medical Journal 11(5): 1113-1124

Kuczynska Sicinska J., 1972: Effect of angiotensin 2 on arterial blood pressure glomerular filtration rate and urinary sodium excretion in normal pregnant and hypertensive rats. Polish Medical Journal (English Translation of Polskie Archiwum Medycyny Wewnetrznej) 11(5): 1113-1124

Ohno A.; Naruse M.; Kato S.; Hosaka M.; Naruse K.; Demura H.; Sugino N., 1992: Endothelin specific antibodies decrease blood pressure and increase glomerular filtration rate and renal plasma flow in spontaneously hypertensive rats. Objective: Studies were undertaken to clarify the pathophysiologic significance of endogenous endothelin in the control of blood pressure and renal hemodynamics in spontaneously hypertensive rats (SHR). Design: The technique of passive immunizatio...

Paulsen, E.P.; Pauly, F.L.; Croft, B.Y.; Teates, C.D., 1990: Simultaneous measurement of glomerular filtration rate and effective renal plasma flow reveals increased glomerular capillary pressure among teenage diabetic subjects. Contributions to Nephrology 79: 52-57

Gothberg G.; Folkow B., 1983: Structural auto regulation of blood flow and glomerular filtration rate in the 2 renal vascular beds from 2 kidney 1 clip renal hypertensive rats as compared with kidneys from uni nephrectomized and intact normotensive rats. Both kidneys from 2-kidney, 1-clip renal hypertensive rats (RHR) and the hypertrophied kidney of uninephrectomized rats (UNR) were investigated during artificial perfusion with 2% Dextran solution and kerosene at maximal vasodilatation and studied...

Blantz R.C.; Rector F.C.Jr; Seldin D.W., 1972: Effect of hyper oncotic albumin expansion on glomerular hydrostatic pressure effective filtration pressure glomerular permeability and nephron filtration rate in the rat. Clinical Research 20(3): 587

Peters, A.Michael.; Glass, D.M.; Bird, N.J., 2010: Slope-only glomerular filtration rate and single-sample glomerular filtration rate as measurements of the ratio of glomerular filtration rate to extracellular fluid volume. The Jacobsson single-sample equation for measuring glomerular filtration rate (GFR) after bolus injection is based on two factors of questionable theoretical validity for correcting the single-compartment assumption. The aims were to redevelop a m...