EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of glucosamine 6 phosphate deaminase ec 2.7.1.59 synthesis in yeast


Biochimica et Biophysica Acta 583(1): 28-35
Regulation of glucosamine 6 phosphate deaminase ec 2.7.1.59 synthesis in yeast
A basal level of glucosamine-6-phosphate deaminase [EC 2.7.1.59] is detected in yeast cells grown on glucose. However, a burst of enzyme production occurs in the presence of N-acetylglucosamine in pathogenic Candida albicans and non-pathogenic Saccharomyces cerevisiae. The enzyme synthesis stops and its concentration in the cells declines rapidly as soon as N-acetylglucosamine is removed from the medium. Experiments with RNA- and protein-synthesis inhibitors indicate that the appearance of new enzyme activity is dependent on concomitant new protein synthesis and the inducer operates at a transcriptional level. However, inhibition of DNA synthesis either by hydroxyurea or by mitomycin-C does not impair the synthesis of glucosamine-6-phosphate deaminase.


Accession: 006288049



Related references

Regulation of glucosamine-6-phosphate deaminase synthesis in yeast. Biochimica et Biophysica Acta 583(1): 28-35, 1979

Allosteric regulation of glucosamine-6-phosphate deaminase (NagB) and growth of Escherichia coli on glucosamine. Journal of Bacteriology 191(20): 6401-6407, 2009

Uptake and metabolism of derivatives of 2 deoxy 2 amino d glucose in bifidobacterium bifidum var pennsylvanicus lactobacillus bifidus var pennsylvanicus enz glucosamine 6 phosphate synthetase enz n acetyl glucosamine kinase enz n acetyl glucosamine 6 phosphate deacetylase enz glucosamine 6 phosphate deaminase. Archives Of Biochemistry & Biophysics: 248-256, 1969

Engineering a new pathway for N-acetylglucosamine production: Coupling a catabolic enzyme, glucosamine-6-phosphate deaminase, with a biosynthetic enzyme, glucosamine-6-phosphate N-acetyltransferase. Enzyme and Microbial Technology 39(4): 828-834, 2006

On the multiple functional roles of the active site histidine in catalysis and allosteric regulation of Escherichia coli glucosamine 6-phosphate deaminase. Biochemistry (American Chemical Society) 40(34): 187-96, 2001

On the multiple functional roles of the active site histidine in catalysis and allosteric regulation of Escherichia coli glucosamine 6-phosphate deaminase. Biochemistry 40(34): 10187-10196, 2001

Phosphoric esters of biological importance VI The synthesis of D-glucosamine 6-phosphate and N-acetyl-D-glucosamine 6-phosphate and N-acetyl-D-glucosamine 6-phosphate. Jour Amer Chem Soc: 1393-1397, 1956

Glucosamine metabolism IV Glucosamine 6-phosphate deaminase. 1958

Glucosamine metabolism. IV. Glucosamine-6-phosphate deaminase. Journal of Biological Chemistry 232(2): 807-827, 1958

Synthesis of glucosamine 6 phosphate by the activity of glutamine hexose phosphate amido transferase and of glucosamine kinase in eggs and embryos of paracentrotus lividus. Italian Journal Of Biochemistry (english Edition): 382-393, 1969