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Regulation of glutamate dehydrogenase in Bacillus subtilis


, : Regulation of glutamate dehydrogenase in Bacillus subtilis. Journal of Bacteriology 148(3): 1002-1005

The activity of the nicotinamide adenine dinucleotide-dependent glutamate dehydrogenase in Bacillus subtilis was influenced by the carbon source, but not the nitrogen source, in the growth medium. The highest specific activity for this enzyme was found when B. subtilis was grown in a minimal or rich medium that contained glutamate as the carbon source. It is proposed that glutamate dehydrogenase serves a catabolic function in the metabolism of glutamate, is induced by glutamate, and is subject to catabolite repression.

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Accession: 006288101

PMID: 6118356

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Related references

Belitsky, B.R.; Sonenshein, A.L., 1998: Role and regulation of Bacillus subtilis glutamate dehydrogenase genes. The complete Bacillus subtilis genome contains two genes with the potential to encode glutamate dehydrogenase (GlutDH) enzymes. Mutations in these genes were constructed and characterized. The rocG gene proved to encode a major GlutDH whose synthe...

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