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Regulation of glutamate oxidation in mitochondria of xenopus laevis oocytes

Comparative Biochemistry & Physiology B 66(1): 1-12
Regulation of glutamate oxidation in mitochondria of xenopus laevis oocytes
Glu is metabolized mainly by transamination to Asp. Reductive deamination by GDH [glutamate dehydrogenase] is found in 1/3 of all Glu that disappeared. Glu transamination of Ala is negligible. NADH and 2-oxoglutarate concentrations involve a glutamate-stat by acting both on the GDH system and on the GOT-MDH [glutamate oxaloacetate transaminase-malate dehydrogenase] coupled system: the extremely low equilibrium constants of these 2 systems support Glu formation. Equilibrium constant of the GOT-MDH coupled system is 4.05 .times. 10-5 at C, pH 7.4. Oxaloacetate available, MDH competes with the respiratory chain for NADH. Malic enzyme (NAD+) promoting male oxidation contributes to NADH supply involved in Glu metabolization control.

Accession: 006288107

DOI: 10.1016/0305-0491(80)90077-2

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