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Regulation of glutamine synthetase activity of hepatoma tissue culture cells by glutamine and dexamethasone


, : Regulation of glutamine synthetase activity of hepatoma tissue culture cells by glutamine and dexamethasone. Journal of Biological Chemistry 248(19): 6738-6743


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Related references

Freikoph A.; Kulka R.G., 1975: Specificity of the glutamine binding site involved in the regulation of glutamine synthetase activity in hepatoma tissue culture cells. European Journal of Biochemistry 56(2): 483-492

Crook, R.B.; Louie, M.; Deuel, T.F.; Tomkins, G.M., 1978: Regulation of glutamine synthetase by dexamethasone in hepatoma tissue culture cells. In certain lines of hepatoma tissue culture (HTC) cells, glutamine synthetase (EC 6.3.1.2) specific activity is increased 2.5- to 3-fold by the addition of glucocorticoids to the growth media. Actinomycin D blocks both the induction and deinductio...

Crook, R.B.; Louie, M.; Deuel, T.F.; Tomkins, G.M., 1978: Regulation of glutamine synthetase ec 6.3.1.2 by dexamethasone in hepatoma tissue culture cells. In certain lines of hepatoma tissue culture (HTC) cells, glutamine synthetase (EC 6.3.1.2) specific activity is increased 2.5- to 3-fold by the addition of glucocorticoids to the growth media. Actinomycin D blocks induction and deinduction of glut...

Freikopf, A.; Kulka, R.G., 1975: Specificity of the glutamine-binding site involved in the reguation of glutamine-synthetase activity in hepatoma tissue-culture cells. Glutamine accelerates the degradation of glutamine synthetase in hepatoma tissue culture cells. Compounds structurally related to glutamine were tested for their ability to mimic or antagonize this effect of glutamine. 6-Diazo-5-oxo-L-norleucine,...

Kulka, R.G.; Tokins, G.M.; Crook, R.B., 1972: Clonal differences in glutamine synthetase activity of hepatoma cells. Effects of glutamine and dexamethasone. Journal of Cell Biology 54(1): 175-179

Crook, R.B.; Tomkins, G.M., 1978: Effect of glutamine on the degradation of glutamine synthetase in hepatoma tissue-culture cells. In certain lines of hepatoma tissue-culture cells, the extracellular glutamine concentration regulates the specific activity of glutamine synthetase. By quantifying the radioactivity in immunoprecipitated glutamine synthetase on polyacrylamide gel...

Arad, G.; Freikopf, A.; Kulka, R.G., 1976: Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells. Effects of glutamine on glutamine synthetase (GS) activity of hepatoma tissue culture (HTC) cells were studied with the aid of a specific goat anti-rat GS serum. Immunodiffusion and immunoelectrophoretic tests show that rat liver GS and HTC cell G...

Arad, G.; Kulka, R.G., 1978: Effects of glutamine methionine sulfone and dexamethasone on rates of synthesis of glutamine synthetase ec 6.3.1.2 in cultured hepatoma cells. Glutamine synthetase (EC 6.3.1.2) activity of rat hepatoma tissue culture cells is elevated by corticosteroids and depressed by glutamine. The transfer of cells from high (1-5 mM) to low (0.2-0.4 mM) concentrations of glutamine causes a marked inc...

Arad, G.; Kulka, R.G., 1978: Effects of glutamine, methionine sulfone and dexamethasone on rates of synthesis of glutamine synthetase in cultured hepatoma cells. Glutamine synthetase (EC 6.3.1.2) activity of hepatoma tissue culture cells is elevated by corticosteroids and depressed by glutamine (Kulka, R.G., Tomkins, G.M. and Crook, R.B. (1972) J. Cell Biol., 54, 175--179). The transfer of cells from high...

Louie M.; Crook R.; Deuel T.; Tomkins G.; Morris H., 1974: Regulation of glutamine synthetase in hepatomas and hepatoma culture cells. Federation Proceedings 33(5 PART 2): 1426