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Regulation of glutamine synthetase ec 6.3.1.2 in fed batch cultures of neurospora crassa


, : Regulation of glutamine synthetase ec 6.3.1.2 in fed batch cultures of neurospora crassa. Biochemical and Biophysical Research Communications 78(4): 1234-1240

The effect of the N and C sources in the regulation of glutamine synthetase [EC 6.3.1.2] was studied in fed-batch cultures of N. crassa. The limitation of ammonium in an excess of the C source, leads to an accumulation of .alpha.-ketoglutarate and elevation of glutamine synthetase. The limitation of sucrose in an excess of ammonium results in a decrease in glutamine synthetase activity. Apparently the C source exerts a positive control in the regulation of glutamine synthetase.

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