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Regulation of glutathione transferase and dt diaphorase ec 1.6.99.2 messenger rna species in persistent hepatocyte nodules during chemical hepatocarcinogenesis


, : Regulation of glutathione transferase and dt diaphorase ec 1.6.99.2 messenger rna species in persistent hepatocyte nodules during chemical hepatocarcinogenesis. Proceedings of the National Academy of Sciences of the United States of America 81(16): 5091-5095

c[complementary]DNA probes and in vitro translation analysis were utilized to quantitate the levels of rat liver glutathione transferase (glutathione S-aralkyltransferase; RX:glutathione R-transferase, EC 2.5.1.18) and DT-diaphorase [NAD(P)H:quinone-acceptor oxidoreductase, EC 1.6.99.2] mRNA in persistent hepatocyte nodules included by chemical carcinogens. Within the nodules, glutathione transferase mRNA specific for the Ya/Yc and Yb subunits are increased 3- to 5-fold, respectively, over the levels observed in normal liver or in the liver tissue surrounding the nodules. The level of DT-diaphorase mRNA is increased 5-7-fold within the nodules as compared to surrounding liver tissue or normal liver. When animals were administered 3-methylcholanthrene, a typical inducer of these mRNA in normal animals, a further increase in the glutathione transferase Yb mRNA(s) and DT-diaphorase mRNA was observed in the nodules; however, the Ya/Yc mRNA levels remained unaffected. During chemically induced neoplastic transformation, the mRNA levels for the Yb subunit of glutathione transferase and DT-diaphorase are evidently increased in the nodules but still retain the capacity to be regulated by 3-methylcholanthrene. Although the glutathione transferase Ya/Yc mRNA are also increased in the nodules, they lost their ability to be regulated by 3-methylcholanthrene. Within the nodules there may be a specific defect in the regulatory mechanisms(s) that leads to an induction of the Ya/Yc mRNA in normal tissue by xenobiotics.

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Whanger, P.D.; Weswig, P.H., 1978: Influence of 19 elements on development of liver necrosis in selenium and vitamin e deficient rats. Of the 19 elements investigated, only Ag, Zn and V promoted liver necrosis in rats fed diets deficient in Se and vitamin E. Ag was by far the most effective in promoting this disorder. Co significantly delayed the development of liver necrosis whi...

Wang, Q.; Ye, T.; Jiang, W.; Lin, Z-wu., 2010: Video-assisted thoracoscopic surgery in the treatment of esophageal leiomyoma: a report of 39 cases. To investigate the application and efficacy of video-assisted thoracoscopic surgery in the treatment of esophageal leiomyoma. Clinical data of 39 patients with esophageal leiomyoma from December 2002 to November 2008 treated by video-assisted thor...

Hohl, D., 1992: Der Blaupunktbuntbarsch - ein alter Bekannter unter falschem Namen?. DCG-Informationen, 235: 101-108

Figueroa, M.E.; Skrabanek, L.; Li, Y.; Jiemjit, A.; Fandy, T.E.; Paietta, E.; Fernandez, H.; Tallman, M.S.; Greally, J.M.; Carraway, H.; Licht, J.D.; Gore, S.D.; Melnick, A., 2009: MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as myelodysplastic syndromes (MDSs), are responsive to DNA methyltransf...

Ucko, H., 1928: The peroxidase nature of active iron. Although Baudisch and Welo have claimed that Fe compounds must be classified as active and inactive depending'upon their ability to transfer O from peroxides to easily oxidizable substances, review of methods used in classifying these forms o...

Hu, N.; Lin, C.; Yuan, H.; Zhang, P.; Chen, G.; Wang, P.; Zhao, M.; Qi, D.; Hao, J.; Hu, S.; Wu, G.; Zhu, J., 2016: How to determine the qi arrival and its strength in clinical research. Qi arrival is the meridian qi response to acupuncture stimulation. Through analyzing the relevant concepts of qi arrival and summarizing the general understanding of it in clinic and on the basis of the collection of the relevant literature at hom...

Shelton Inloes B.B.; Broze G.J.Jr; Miletich J.P.; Sadler J.E., 1987: Evolution of human von willebrand factor complementary dna sequence polymorphisms repeated domains and relationship to von willebrand antigen ii. Four cDNAs extending into the 5'-noncoding region of the human von Willebrand factor cDNA have been characterized. Thirty-four residues of amino-terminal protein sequence for von Willebrand antigen II matched that predicted from the cDNA sequ...

Percival, Brandon., 1995: News from the field: the winter report (December 1994, January & February 1995). C.F.O. Journal. July; 293: 149-156

Mekel, M.; Gilshtein, H.; Al-Kurd, A.; Bishara, B.; Krausz, M.M.; Freund, H.R.; Kluger, Y.; Eid, A.; Mazeh, H., 2016: Negative Fine-Needle Aspiration in Patients with Goiter: Should We Doubt It?. Epidemiologic studies demonstrated higher incidence of thyroid cancer in patients with multinodular goiters compared to the general population. The aim of this study was to evaluate the risk of finding significant thyroid cancer in patients underg...

Bergan, J., 1958: Fertilizer experiment in a young Norway-spruce plantation in Troms.. In Norway spruce grown on an iron podzol of morainic type, the 40-50 cm increase in tree height by treatment with 150-300 kg/ha Ca(NO3)2 corresponded to a height-growth increment of 3-4 years. Where NPK applications were made, especially at 150 kg...