EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of glycolysis and purine nucleotide metabolism in the enzymatic phosphorylation system of mucor aromaticus






Weishengwu Xuebao 20(2): 157-165

Regulation of glycolysis and purine nucleotide metabolism in the enzymatic phosphorylation system of mucor aromaticus

The character of glycolysis, the effects of glucose and phosphate on glycolysis and the regulation of purine nucleotide metabolism by M. aromaticus were studied. Although M. aromaticus possess strong fermenting power, the phosphorylation of glucose in M. aromaticus is easily effected by the storage temperature of the mycelia. That may be the key factor affecting glycolysis and phoshorylation of AMP of M. aromaticus. In the reaction system of enzymatic phosphorylation of M. aromaticus, not only the phosphorylation efficiency of AMP, but also the accumulation rate of ATP were affected by the concentration of glucose and the molar ratio of glucose:phosphate (G/P), played an important role in regulating the activation of the enzyme system of glycolysis and purine nucleotide metabolism. The degradation of AMP was inhibited as G/P < 1. The deamination of AMP brought forth the IMP and the decomposition of latter brought forth Ino and/or Hx as G/P .gtoreq. 1. Under certain concentration of glucose, the high concentration of phosphate could inhibit deamination of AMP and decomposition of IMP, and promote phosphorylation of AMP. It seems that under certain concentration of phosphate, the inhibition effect of the phosphate on the activity of AMP deaminase and Ino hydrolase can be eliminated when G/P .gtoreq. 1, AMP was deaminated to form IMP and the latter was further decomposed to Hx. Therefore, G/P play an important regulative role for metabolic pathway of purine nucleotide of M. aromaticus.


Accession: 006288203



Related references

Northw-Inst-Soil-Water-Conserv-Wugong-China, 1977: Mucor used for producing nucleotide derivatives part 1 enzymatic synthesis of atp by mucor. From 76 strains of fungi (Aspergillus, 8: Rhizopus, 13: Mucor, 38; and other fungi 17;) 8 strains of Mucor, which can convert AMP with a conversion rate of over 90% and 5 strains with a conversion rate of over 95%, were selected. The enzymatic con...

Anonymous, 1977: Mucor used for producing nucleotide derivatives. I. Enzymatic synthesis of ATP by Mucor

Schlee, D.; Reinbothe, H., 1970: Purine metabolism and riboflavin production in microorganisms. VII. Regulation of purine nucleotide synthesis through adenine in Candida guilliermondii (Cast.) Lang. et G. Zeitschrift für Allgemeine Mikrobiologie 10(1): 81-84

Namm, D.H., 1973: Myocardial nucleotide synthesis from purine bases and nucleosides. Comparison of the rates of formation of purine nucleotides from various precursors and identification of the enzymatic routes for nucleotide formation in the isolated rat heart. Circulation Research 33(6): 686-695

Cohen A.; Barankiewicz J.; Lederman H.M.; Gelfand E.W., 1983: Purine and pyrimidine metabolism in human t lymphocyte regulation of deoxy ribo nucleotide metabolism. Purine and pyrimidine deoxyribonucleoside metabolism was studied in G1 and S phase human thymocytes and compared with that of the more mature T lymphocytes from peripheral blood. Both thymocyte populations have much higher intracellular deoxyribon...

Galarza, A.; Abad, A., 1977: Purine nucleotide metabolism and its regulation. A deficiency in GMP:5-phosphoribosyl-5-phosphate transferase produces a metabolic unbalance with mental disorders in humans. AMP in excess is synthetized in this disease and the pathway of this nucleotide was studied. AMP produces an inhibitor eff...

Finch L.R.; Mitchell A., 1990: Purine nucleotide metabolism and its regulation in the mollicutes. Zentralblatt fuer Bakteriologie Supplement 20: 172-180

Burton K., 1970: The regulation of purine nucleotide metabolism in bacteria. Bartley, W , H L Kornberg And J R Quayle (Edited By) Essays in Cell Metabolism: Hans Krebs Dedicatory Volume 290p Illus Wiley-Interscience: New York, N Y , U S A ; London, England 67-83

Weber, G.; Jackson, R.C.; Williams, J.C.; Goulding, F.J.; Eberts, T.J., 1976: Enzymatic markers of neoplastic transformation and regulation of purine and pyrimidine metabolism. Advances in Enzyme Regulation 15: 53-77

Burns, V.W., 1964: Regulation And Coordination Of Purine And Pyrimidine Biosyntheses In Yeast. I. Regulation Of Purine Biosynthesis And Its Relation To Transient Changes In Intracellular Nucleotide Levels. The control of purine biosynthesis in a yeast mutant deficient for uracil, adenine, and histidine has been studied in vivo. The adenine mutation causes accumulation of aminoimidazole ribotide in the cells. The control curve relating steady-state p...