+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of glycolysis in skeletal muscle

Life Sciences 19(4): 455-465
Regulation of glycolysis in skeletal muscle
Four hypotheses to explain the several hundred fold activation of phosphofructokinase and thus glycolysis in muscle during muscular contraction were examined. They are: adenine nucleotide control; an extension of this hypothesis with 5'AMP amplifying the change in glycolytic flux by modifying the phosphofructokinase/fructose 1, 6 diphosphatase cycle; synergistic activation of phosphofructokinase by its various effectors; and Ca2+ translocation and compartmentation of phosphofructokinase in the sarcoplasmic reticulum. Synergism among the effectors of phosphofructokinase is perhaps the major mechanism by which its activity is increased by several hundred fold during muscular contraction, and Ca2+ translocation during muscular contraction can activate 25-30% of total cellular phosphofructokinase that is located in the sarcoplasmic reticulum.

Accession: 006288211

PMID: 183077

DOI: 10.1016/0024-3205(76)90223-x

Download PDF Full Text: Regulation of glycolysis in skeletal muscle

Related references

Regulation of glycolysis in muscle III Influence of insulin, epinephrine, and contraction on phosphofructokinase activity in skeletal muscle. 1964

Regulation Of Glycolysis In Muscle. 3. Influence Of Insulin, Epinephrine, And Contraction On Phosphofructokinase Activity In Frog Skeletal Muscle. Journal of Biological Chemistry 239: 3246-3252, 1964

In situ regulation of glycolysis in tetanized cat skeletal muscle. Arch Biochem Biophys 120(3): 542-546, 1967

Post-mortem glycolysis in skeletal muscle. The extent of glycolysis in diluted preparation of mammalian muscle. Biochemical Journal 97(1): 1-6, 1965

The role of fructose-1,6-diphosphatase in the regulation of glycolysis in skeletal muscle. Febs Letters 7(2): 195-198, 1970

The role of fructose 1 6 di phosphatase ec 31311 in the regulation of glycolysis in skeletal muscle. 1970

Role of oxygen in regulation of glycolysis and lactate production in human skeletal muscle. Exercise and Sport Sciences Reviews 18: 1-28, 1990

Theoretical studies on the regulation of anaerobic glycolysis and its influence on oxidative phosphorylation in skeletal muscle. Biophysical Chemistry 110(1-2): 147-169, 2004

Regulation of glycolysis. III. Influence of insulin, epinephrine, and contraction on phosphofructokinase activity in frog skeletal muscle. Journal of Biological Chemistry, 239: 3146-3152, 1964

The effect of diet on multiple site regulation of glycolysis in rat skeletal muscle 1. glucose metabolism and intracellular metabolites. Nutrition Research 9(7): 735-750, 1989