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Regulation of glycolysis in skeletal muscle


, : Regulation of glycolysis in skeletal muscle. Life Sciences 19(4): 455-465

Four hypotheses to explain the several hundred fold activation of phosphofructokinase and thus glycolysis in muscle during muscular contraction were examined. They are: adenine nucleotide control; an extension of this hypothesis with 5'AMP amplifying the change in glycolytic flux by modifying the phosphofructokinase/fructose 1, 6 diphosphatase cycle; synergistic activation of phosphofructokinase by its various effectors; and Ca2+ translocation and compartmentation of phosphofructokinase in the sarcoplasmic reticulum. Synergism among the effectors of phosphofructokinase is perhaps the major mechanism by which its activity is increased by several hundred fold during muscular contraction, and Ca2+ translocation during muscular contraction can activate 25-30% of total cellular phosphofructokinase that is located in the sarcoplasmic reticulum.

Accession: 006288211

PMID: 183077

DOI: 10.1016/0024-3205(76)90223-x

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Related references

Anonymous, 1964: Regulation of glycolysis in muscle III Influence of insulin, epinephrine, and contraction on phosphofructokinase activity in skeletal muscle

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