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Regulation of gmp content in deep cerebellar nuclei

Neuroscience 2(1): 49-52

Regulation of gmp content in deep cerebellar nuclei

The cyclic[c]GMP content of deep cerebellar nuclei of rats was decreased following activation of GABA receptors by muscimol and diazepam and was increased following a reduction of GABA content caused by isoniazid. The cGMP content of deep cerebellar nuclei may be an index of the activity of these neurons. Neither the destruction nor the specific activation of climbing fibers changed the cGMP content of deep cerebellar nuclei. Morphine and haloperidol decreased the cGMP content of deep cerebellar nuclei without changing the activity of enzymes that metabolize cGMP in cell free preparations or by activating GABA receptors or changing GABA content. A decrease in mossy fiber activity probably mediated the decrease in the cGMP content of deep cerebellar nuclei induced by morphine and haloperidol injected parenterally.

Accession: 006288231

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