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Regulation of gonadotropin release by luteinizing hormone releasing hormone and estrogen in chimpanzees pan troglodytes


, : Regulation of gonadotropin release by luteinizing hormone releasing hormone and estrogen in chimpanzees pan troglodytes. Endocrinology 105(1): 269-275

Plasma LH [luteinizing hormone] and FSH [follicle stimulating hormone] levels were determined by RIA [radioimmunoassay] before and after an i.v. bolus of LHRH [luteinizing hormone releasing hormone] in adult female chimpanzees. The pre-LHRH concentration of 17.beta.-estradiol (E2) was determined by RIA. Menstruating and postpartum chimpanzees (mean E2, 29.8 and 45.0 pg/ml, respectively) showed a monophasic LH response characterized by a 2- to 3-fold increase in LH levels within 15 min of LHRH injection, followed by a slow decline. In animals which had elevated estrogen levels, namely midfollicular animals (mean E2, 73.6 pg/ml), menstruating animals pretreated with 5 .mu.g estradiol benzoate for 2 days (mean E2, 283.2 pg/ml), and postpartum chimpanzees administered 50 .mu.g mestranol/day for 7 days, LH showed a reduced or similar initial rise, followed by a plateau or slight decline during the first 60 min after LHRH but, thereafter, a progressive secondary increase that continued throughout the second 60 min. This secondary augmentation was greatly exaggerated when a long acting LHRH analog (desGly10-[D-Trp6, Pro9, NEt[ethylamide]]LHRH) was administered. FSH responses were inhibited during the first 2 h when estrogen levels were elevated, except in animals administered the long acting analog which showed a secondary augmentation of FSH after 3 h. The relative gonadotropin increment after LHRH administration in the chimpanzee is similar to the human; estrogen can differentially modulate the LH and FSH responses to LHRH, partly by preferential augmentation of LH release, as seen in this study 1 h after LHRH challenge.

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