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Regulation of gonadotropin secretion in post menopausal depressed women after hysterectomy in a internal medicine clinic


, : Regulation of gonadotropin secretion in post menopausal depressed women after hysterectomy in a internal medicine clinic. Japanese Journal of Psychosomatic Medicine 21(2): 123-130

Plasma gonadotropin secretion was studied after infusion of LH-RH (luliberin). The subjects were postmenopausal depressed women who had had a hysterectomy. Psychological tests and an autonomic function test using microvibration were carried out. Apparently, hysterectomy in climacterium was important as a risk to cause depression. Literature surveys were made of hysterectomy and depression. Plasma LH (lutropin) concentration in primary depression was less than that in the control and in secondary depression. Plasma FSH (follitropin) concentration showed no significant differences between 3 groups (control, primary depression and secondary depression). Plasma LH concentration in LH-RH test revealed high responses in the order of primary depression, control and secondary depression. Plasma FSH showed no significant differences between 3 groups. The mean of LH concentration after LH-RH in 5 primary depressions revealed hypo-poor response and the mean of LH in secondary depression revealed hyper-well response. When comparisons were made between the anxiety type and the retarded type in clinical features of depression, gonadotropin response in LH-RH revealed no significant differences between primary depression and secondary depression. All patients with the retarded type of depression were classified under primary depression. Comparisons among psychological tests revealed that V items and M-R items of CMI (Cornell Medical Index) and MAS (Manifest Anxiety Scale) scores had no significant difference. SRQ-D in primary depression increased more significantly than in secondary depression. Plasma gonadotropin secretion was little affected by hysterectomy. The change of LH and FSH secretion might be influenced by affective disorders.

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