EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of gonadotropin secretion in Turner's syndrome






New England Journal of Medicine 298(24): 1328-1331

Regulation of gonadotropin secretion in Turner's syndrome

To determine the role of body fat in regulating secretion of luteinizing hormone and follicle-stimulating hormone, we measured both at 20-minute intervals for 24 hours in eight children with Turner's syndrome. The 24-hour mean luteinizing hormone levels varied from 20.2 to 70.5 mlU per milliliter. Total body weight, total body fat and percentage of body fat showed a significant negative correlation with the 24-hour mean luteinizing hormone concentrations (P less than 0.01). The 24-hour mean follicle-stimulating hormone concentrations ranged from 60.4 to 229 mlU per milliliter, with a significant negative correlation between total body fat and percentage body fat and the 24-hour mean concentrations (P less than 0.05). These negative correlations were not mediated by estrogens or androgens.


Accession: 006288249

PMID: 651991

DOI: 10.1056/NEJM197806152982402



Related references

Warman, D.M.; Guercio, G.; Chaler, E.; Maceiras, M.; Rivarola, M.; Belgorosky, A., 1997: Influence of growth hormone treatment in the regulation of gonadotropin secretion in patients with Turner syndrome. Hormone Research (Basel) 48(SUPPL 2): 132

Rudolf, K.; Kunkel, S.; Delzer, W., 1985: Influence of mestranol and chlormadinone acetate on basal and gonadotropin releasing hormone stimulated secretion of gonadotropin in turner's syndrome. In 19 patients aged from 12 to 24 years (average age 17,0 years) with Turner's syndrome the influence of mestranol and chlormadinone acetate on both basal and GnRH stimulated secretion of gonadotropins was investigated by means of sequential...

Hosoda, A.; Fujieda, K.; Matsuura, N.; Okuno, A.; Yuri, K., 1991: Age-related change of pulsatile gonadotropin secretion in Turner syndrome. In an attempt to understand the dynamic change of the gonadotropin-releasing hormone-pituitary axis during the transitional stage from prepuberty to puberty, we investigated gonadotropin secretory patterns using a highly sensitive assay system and...

Chrysis, D.; Spiliotis, B.E.; Stene, M.; Cacciari, E.; Davenport, M.L., 2006: Gonadotropin secretion in girls with turner syndrome measured by an ultrasensitive immunochemiluminometric assay. Background/Aim: Gonadortropin levels measured by radioimmunoassays are high in girls with Turner syndrome (TS), but overlap significantly with those of normal girls. We hypothesized that gonadotropin levels would be above the normal range in TS wh...

Rudolf, K.; Kunkel, S.; Delzer, W., 1985: Effect of mestranol and chlormadinone acetate on basal and GnRH stimulated gonadotropin secretion in Turner's syndrome. In 19 patients aged from 12 to 24 years (average age 17.0 years) with Turner's syndrome the influence of mestranol and chlormadinone acetate on both basal and GnRH stimulated secretion of gonadotropins was investigated by means of sequential...

Ohzeki, T.; Egi, S.; Kagawa, J.; Nagafuchi, S.; Igarashi, Y.; Hanaki, K.; Ishitani, N.; Motozumi-Wakatsuki, H.; Sunaguchi, M., 1989: Prolonged suppression of gonadotropin secretion after weight recovery in an anorectic patient with Turner's syndrome: reduced gonadal function in anorexia nervosa is independent in part on nutrition. Two hypotheses have been postulated as to the pathogenesis of hypogonadotropinemia in anorexia nervosa; one is starvation and weight loss and the other is a psychological factor to influence gonadotropin secretion. Our patient suffered from very r...

Tanaka, T.; Hibi, I.; Shizume, K., 1991: GH-secretion capacity in Turner syndrome and its relations to clinical characteristics and effect of GH treatment--a comparison with pituitary dwarfism. The Committee for hGH treatment in Turner syndrome. The relations of GH secretion capacity by stimulation tests to clinical characteristics and the effect of GH treatment were studied in 151 girls with Turner syndrome and were compared with those in 128 patients with pituitary dwarfism. GH secretio...

Arita, J., 1979: Roles of biogenic amines in the brain in the regulation of gonadotropin secretion. II. The effects of neural transections in the rat midbrain on gonadotropin secretion [author's transl). Nihon Naibunpi Gakkai Zasshi 55(11): 1425-1436

Cavallo, L.; Gurrado, R., 2000: Endogenous growth hormone secretion does not correlate with growth in patients with Turner's syndrome. Italian Study Group for Turner Syndrome. We investigated in Turner's syndrome patients whether the decrease in growth hormone (GH) secretion is frequent or sporadic, whether or not reduced GH secretion contributes to insufficient growth, and whether age, spontaneous presence of tela...

McCartney, C.R.; Eagleson, C.A.; Marshall, J.C., 2003: Regulation of gonadotropin secretion: implications for polycystic ovary syndrome. Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism and chronic anovulation. Although the etiology of PCOS is unknown, perturbations of gonadotropin secretion are one of the hallmarks of this disorder. In normal menstr...