+ Translate

Regulation of granulopoiesis following severe thermal injury

, : Regulation of granulopoiesis following severe thermal injury. Journal of Trauma 23(1): 19-24

Neutropenia often accompanies septicemia in burned patients. This paradox suggests a defect in the regulation of granulopoiesis. Colony stimulating factor (CSF) produced by the monocyte-macrophage system is an important regulator of granulocyte production. We followed serial serum CSF levels and peripheral blood leukocyte differential counts in 22 patients with greater than 30% burns. Six patients (mean burn, 58%) developed Gram-negative septicemia and died (Group I). Sixteen patients (mean burn, 38%) had no fatal septicemias (Group II). Nonsurvivors had initially low levels of CSF and developed persistent monocytopenia. Survivors, in contrast, had prompt rises in CSF and developed monocytosis. The presence of monocytopenia and low CSF levels in Group I suggests an abnormality in the stimulatory arm regulating granulopoiesis. Such a defect may play a role in the development of fatal septicemia following severe thermal injury.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288263

PMID: 6401816

DOI: 10.1097/00005373-198301000-00004

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

John E. Vidale; Douglas Garcia-Gonzalez, 1988: Seismic observation of a high-velocity slab 1200-1600 km in depth. Geophysical Research Letters 15(4): 369

Lourenco, Wilson R.; Monod, Lionel., 1999: Confirmation of the validity of the genus Hormiops Fage, 1933 with redescription of Hormiops davidovi Fage, 1933 Scorpiones, Ischnuridae Confirmation de la validite du genre Hormiops Fage, 1933 avec redescription d Hormiops davidovi Fage, 1933 Scorpiones, Ischnuridae. Study of the types and specimens of scorpions belonging to the genus Hormiops Fage, 1933, deposited in the Museum national d'Histoire naturelle, Paris, leads to the revalidation of this genus, with a redescription of Hormiops davidovi Fage, 1...

Goodwin, J. K.; Cooper, R. C.; Weber, W. J., 1992: The medical management of pets with congenital heart defects. Guidelines for the medical management of congenital heart diseases are outlined. Specific conditions covered include left- and right-sided congestive heart failure, atrial fibrillation; supraventricular tachycardia, ventricular arrhythmias, hypoxa...

Chou, C.K.; Su, T.S.; Chang, C.M.; Hu, C.P.; Huang, M.Y.; Suen, C.S.; Chou, N.W.; Ting, L.P., 1989: Insulin suppresses hepatitis B surface antigen expression in human hepatoma cells. The human hepatoma Hep3B cells contain integrated hepatitis B viral genome and continually secret hepatitis B surface antigen (HBsAg). The production of HBsAg (but not alpha-fetoprotein) was suppressed by addition of low concentrations (0.1-1 nM)...

Cabou, Cendrine; Bagheri, Haleh; Cantagrel, Alain; Mazieres, Bernard; Montastruc, Jean-Louis, 2003: Analyse retrospective des effets indesirables de l'infliximab dans un service hospitalier de rhumatologie. Infliximab is a chimeric monoclonal antibody against human tumour necrosis factor-alpha (TNFalpha), and has received marketing authorisation for the treatment of both rheumatoid arthritis (RA) and Crohn's disease. The aim of the present surve...

Tokioka, T., 1955: On some plankton animals collected by the Syunkotu Maru in May-June 1954. III. Appendicularians. Bulletin of the Biogeographical Society of Japan, 16-19: 251-255

Paludo, G. R.; McManus, C.; Melo, R. Q. de; Cardoso, A. G.; Mello, F. P. da S.; Moreira, M.; Fuck, B. H., 2002: Effect of heat stress and exercise on physiological parameters of horses of the Brazilian army. The horses of the Brazilian army are used for expositions, and frequently subjected to intense exercise. This, together with environmental conditions of the Central west savanna result in the need for acclimatization. The objective of this study w...

Rocchi L.; Grata M.L.; Farinatti M.T.; Mantovani P.; Tasini M.T., 1988: Diffusion of hepatitis b markers in a population of the district of ferrara italy. A high percentage (30.4%) of 1000 subjects in the east of Ferrara district shows HBV markers. 2.9% are carriers of HBsAg. The same percentage was found in the hospital workers in the same district. The carriers of HBV markers increase with age.

Hirono, J.; Sato, T.; Kataoka, Y.; Kaetsu, I., 1999: Tuning specificities to aliphatic compounds and cyclic compounds in mouse olfactory receptor cells. Biophysical Journal 76(1 PART 2): A115, Jan

Ladd, L.A.; Chang, D.H-T.; Wilson, K.A.; Copeland, S.E.; Plummer, J.L.; Mather, L.E., 2002: Effects of CNS site-directed carotid arterial infusions of bupivacaine, levobupivacaine, and ropivacaine in sheep. Background: Previous preclinical safety studies in ewes have found intravenous levobupivacaine and ropivacaine to be less potent toward causing central nervous system (CNS) and cardiac toxicity than bupivacaine. Analogous cardiotoxicity has been d...