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Regulation of guanylate cyclase ec 4.6.1.2 and adenylate cyclase activities by lyso lecithin


, : Regulation of guanylate cyclase ec 4.6.1.2 and adenylate cyclase activities by lyso lecithin. Proceedings of the National Academy of Sciences of the United States of America 73(5): 1586-1590

The guanylate cyclase activity [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] in membrane preparations from 3T3 mouse fibroblasts is stimulated approximately 5-fold by lysolecithin at concentrations of 100 .mu.g/ml and above. The stimulation of the adenylate cyclase activity in these preparations by sodium fluoride is inhibited up to 95% by lysolecithin over a similar concentration range. The regulatory properties of lysolecithin appear to result from the surfactant properties of the phospholipid, since the activity cannot be attributed to any single substructure within the molecule and lysolecithin affects the subcellular distribution of guanylate cyclase in rat heart homogenates in a manner similar to that reported for the non-ionic detergent Triton X-100. Stimulation of guanylate cyclase by lysolecithin was observed with membrane preparations from both 3T3 cells and simian virus 40 transformed 3T3 cells (SV3T3). A possible role for lysolecithin in the coordinate regulation of the intracellular levels of both cyclic nucleotides and in the control of the responsiveness of target tissues to hormone or mitogen stimulation is suggested.

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Dutkevich, I.G.; Farshatov, M.N.; Glebov, I.I.; Dekster, B.G., 1966: The use of regional artificial circulation in the treatment of obliterating thrombosis of the lower limbs. Vestnik Khirurgii Imeni I. I. Grekova 96(6): 122-126

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Kloos, H.; McCullough, F.S., 1985: Ethiopian plants with proven and suspected molluscicidal activity: a new approach in plant evaluation. Using available information on the toxicity, phytochemistry, ethnomedical uses and geographic distribution of plants, potentially suitable species are identified for the control of intermediate hosts of schistosomiasis in Ethiopia's lowlands...

Ziebart, T.; Ziebart, J.; Gauss, L.; Pabst, A.; Ackermann, M.; Smeets, R.; Konerding, M.A.; Walter, C., 2014: Investigation of inhibitory effects on EPC-mediated neovascularization by different bisphosphonates for cancer therapy. Bisphosphonates (BPs) are potent drugs, used in metastatic cancer-like prostate or breast carcinoma. In recent studies, besides reduced bone remodeling, influences on angiogenesis and neovascularization were reported. Since BPs have the tendency t...

Troup, G.M.; Schanfield, M.S.; Singaraju, C.H.; Harvey, R.L.; Jameson, J.; Capper, J.; Baker, B., 1982: Study of HLA alloantigens of the Navajo Indians of North America. II. HLA-A, B, C, DR and other genetic markers. This report presents the antigen frequencies for HLA-A, B, C, DR, immunoglobulin, and red blood cell systems for the Navajo Indians of North America. HLA-A-B,B-C, and B-DR haplotype frequencies and significant delta values are given. These data ar...

Mitani, M.M.; Keller, A.A.; Bunton, C.A.; Rinker, R.G.; Sandall, O.C., 2001: Kinetics and products of reactions of MTBE with ozone and ozone/hydrogen peroxide in water. Methyl-t-butyl-ether (MTBE) has become a prevalent groundwater pollutant due to its high volume use as a nationwide gasoline additive. Given its physicochemical properties, it requires new treatment approaches. Both aqueous O(3) and a combination...

Poste G.; Kirsh R.; Fidler I.J., 1979: Cell surface receptors for lymphokines part 1 the possible role of glyco lipids as receptors for macrophage migration inhibitory factor and macrophage activation factor. Incubation of culture supernatants from concanavalin [Con] A-stimulated guinea pig and rat lymphocytes with protein-free preparations of bovine brain gangliosides abolished their macrophage migration inhibitory factor (MIF) and macrophage activati...

Nikolaeva V.V., 1971: Microwave therapy of patients with obliterating diseases of the peripheral vessels. Voprosy Kurortologii Fizioterapii i Lechebnoi Fizicheskoi Kul'tury 36(6): 496-502

Prekht, K.; Raĭnshke, P.; Klinkman, K.; Sal'nik, G.A., 1987: Results of substitution therapy of kidney diseases in East Germany. Terapevticheskii Arkhiv 59(8): 96-97

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