+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of heme and drug metabolism activities in the brain by manganese

, : Regulation of heme and drug metabolism activities in the brain by manganese. Biochemical & Biophysical Research Communications 128(1): 18-24

A novel effect of metal ions in the [rat] brain is described. Mn altered heme metabolism and the cytochrome P-450-dependent mixed-function oxidase activities in rat brain. A more than 2-fold increase in benzo(.alpha.)pyrene hydroxylase and 7-ethoxycoumarin deethylase activities were observed in the brain of rats treated for 7 days with Mn. The increases were regionally distributed; the highest elevations were observed in the hippocampus, pons and the caudate putamen. Moreover, in rats treated with Mn for 1 or 7 days a marked depression in the activity of the mitochondrial .delta.-aminolevulinate synthetase was observed. The activity of the microsomal heme oxygenase was also inhibited at 7 days, but not 1 day, after Mn treatment. These inhibitions were reflected in an initial decrease, followed by a rebound return to normal, in the concentration of cytochrome P-450 in the brain. Mn was ineffective in vitro in altering heme and drug metabolism activities. Mn-mediated alterations in heme matabolic activities may promote changes in the composition of cytochrome P-450 species in the brain microsomal fractions, such that the relative concentrations of the molecular species which catalyze aryl hydrocarbon hydroxylase activity become selectively increased.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288337

PMID: 3921022

DOI: 10.1016/0006-291x(85)91638-9

PDF Full Text: Regulation of heme and drug metabolism activities in the brain by manganese

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Moertel, C.G.; Fleming, T.R.; Macdonald, J.S.; Haller, D.G.; Laurie, J.A.; Tangen, C.M.; Ungerleider, J.S.; Emerson, W.A.; Tormey, D.C.; Glick, J.H.; Veeder, M.H.; Mailliard, J.A., 1995: Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Objective: To determine the effectiveness of two adjuvant therapy regimens in improving surgical cure rates in stage III (Dukes stage C) colon cancer. Design: Randomized, concurrently controlled clinical trial. Setting: Major cancer centers, unive...

Bril, B., 1987: Parades du harle piette Mergus albellus. Heron, 203: 196

Moore, E.P.; Copeland, E.M.; Dudrick, S.J.; Weisbrodt, N.W., 1976: Effect of an elemental diet on the electrical activity of the small intestine in dogs. Journal of Surgical Research 20(6): 533-537

Homonko, D.; Theriault, E.; Marshall, K. W., 1993: Increased substance P and calcitonin gene-related peptide immunoreactivity in feline knee joint afferent projections in chronic arthritis. Society for Neuroscience Abstracts 19(1-3): 1564

Nillegoda, N.B.; Theodoraki, M.A.; Mandal, A.K.; Mayo, K.J.; Ren, H.Yu.; Sultana, R.; Wu, K.; Johnson, J.; Cyr, D.M.; Caplan, A.J., 2010: Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins. Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae...

Mohamed, F. H. A.; Cox, J. E., 1988: Studies of pituitary adrenal testis interaction in sheep ii. the effects of repeated injections of acth outside the breeding season. The administration of 0.5 mg of long-acting adrenocorticotrophic hormone (ACTH, Synacthen-Depot) twice daily for 5.5 d to four rams outside the breeding season caused marked rises in plasma cortisol without any evidence of adrenal depletion. This...

Chikwe, J.; Kim, M.; Goldstone, A.B.; Fallahi, A.; Athanasiou, T., 2011: Current diagnosis and management of left main coronary disease. Left main coronary artery (LMCA) disease remains an important risk factor for increased mortality and morbidity at all stages of diagnosis and treatment of coronary artery disease. Left main stem pathology is often silent, with unpredictable prese...

Shultz, D; Bollman, Sl; Kumar, R., 1982: Binding of 1,25-dihydroxyvitamin D3 to crude intestinal cytosol preparations: evidence for curvilinear scatchard plots. Vitamin D chemical biochemical and clinical endocrinology of calcium metabolism: proceedings of the Fifth Workshop on Vitamin D Williamsburg VA USA February 1982 editors AW Norman et al: 107

Marlow, H.M.; Tolley, E.E.; Weaver, M.A.; Kohli, R.; Mehendale, S., 2013: Changes in condom use during a microbicide clinical trial in Pune, India. Researchers have raised concerns that microbicide use during clinical trials would displace condom use. We sought to understand whether condom use changed for participants in a microbicide clinical trial in Pune, India, to understand whether condo...

Pandey, S.K.; Jogdand, G.F.; Oliveira, Jão.C.A.; Mata, R.A.; Rajamohanan, P.R.; Ramana, C.V., 2012: Synthesis and structural characterization of homochiral homo-oligomers of parent cis- and trans-furanoid-β-amino acids. The synthesis of homochiral homo-oligomers of cis- and trans-3-aminotetrahydrofuran-2-carboxylic acids (parent cis- and trans-furanoid-β-amino acids, referred to as "cis-/trans-FAA") has been carried out to understand their secondary st...