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Regulation of heme metabolism during senescence activity of several heme containing enzymes and heme oxygenase in the liver and kidney of aging rats

, : Regulation of heme metabolism during senescence activity of several heme containing enzymes and heme oxygenase in the liver and kidney of aging rats. Mechanisms of Ageing & Development 12(1): 81-92

The activities of several heme-containing enzymes plus succinate dehydrogenase, the content of mitochondrial cytochromes, the amount of microsomal cytochrome P-450, and the activity of heme oxygenase, the major enzyme of heme degradation, have been compared in young, mature and senescent rats. Measurements were made in liver, a tissue previously reported to have an age-related decrease in .delta.-aminolevulinic acid synthetase, and in kidney, a tissue previously reported to have no age-related change in this enzyme, the rate-limiting enzyme of heme biosynthesis. The activity of cytochrome oxidase in liver mitochondria did not decrease with age while this activity in kidney mitochondria was highest in animals 1 yr old and decreased in the 2 yr olds. Succinate dehydrogenase of both kidney and liver mitochondria decreased markedly in the aging rats. No age-related change in the content of cytochromes b, c or aa3 was observed in liver mitochondria; however, a marked age-related decrease in cytochrome aa3 was observed in kidney mitochondria. Similarly no change in cytochrome P-450 levels was observed in either tissue obtained from aging animals. In the liver, catalase activity increased while in the kidney it decreased in senescent as compared to mature animals. Heme degradation does not decrease with age as the activity of heme oxygenase increased in both liver and kidney of 2 yr old rats as compared to 1 yr olds. The lower activity of .delta.-aminolevulinic acid synthetase observed in the aging rat may not be correlated with a decrease in the activity of heme-containing proteins and the regulation of the heme pool used for the synthesis of various intracellular hemoproteins may be complex.

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Accession: 006288341

PMID: 6243730

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