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Regulation of heme synthesis in hepg2 human hepatoma cells by dmso


, : Regulation of heme synthesis in hepg2 human hepatoma cells by dmso. Biochemical & Biophysical Research Communications 153(2): 869-874

Dimethyl sulfoxide (DMSO) treatment of human HepG2 hepatoma cells increases the activity and the concentration of .delta.-aminolevulinic acid dehydratase (ALAD) to a comparable degree. Results of experiments with transcriptional inhibitors suggest that the increase in ALAD reflects de novo synthesis of the enzyme resulting from transcriptional activation. Commitment to increased ALAD activity in HepG2 cells is seen after 18 hr and complete by 48 hr. In contrast to the effects on ALAD, DMSO decreases the activities of porphobilinogen deaminase and uroporphyrinogen decarboxylase.

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Car, M.; Znidar, A.; Filipan, T., 1967: Effect of STH (growth hormone) on retention of N in intensive feeding of young cattle. Eight Simmental bullocks about a year old were divided into 2 groups and studied for 3 successive periods of 44 days, initial and final control periods and a test period in which the experimental but not the control group got 140 mg growth hormone...

Rizzardini M.; Abeliuk P., 1971: Tyrosinemia and tyrosinuria in low birth weight infants a new criterion to assess maturity at birth. American Journal of Diseases of Children 121(2): 182-185

Constantinescu, Gs; Krajewski, Wf; Ozdemir, Ce; Tokyay, T., 2007: Simulation of airflow around rain gauges: Comparison of LES with RANS models. Wind is responsible for systematic errors that affect rain gauge measurements. The authors investigate the use of computational fluid dynamics (CFD) to calculate airflow around rain gauges by applying a high-resolution large eddy simulation (LES)...

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Paoletti, M. G.; Dreon, A. L.; Lorenzoni, F. C., 2001: Hedgerows in the Mediterranean region: a multifunctional system which links diversity with the history of cultivated plants. In the Mediterranean region, hedgerows, field margins and terracing are, in most cases, remnants of past practice in terms of species combination and landscape structure. These marginal combinations of plant and animal life represent what remains...

Foster, W. J.; Harbour, J. W., 2002: Alterations of the Neurofibromatosis Type 1 Tumor Suppressor Locus in Uveal Melanoma. Purpose: Although uveal melanoma is the most common primary ocular malignancy, the genetic abnormalities that lead to this cancer remain poorly understood. Tumor suppressor genes such as p53, Rb, and p16 are not mutated in the majority of uveal me...