+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of hemo globin synthesis during the development of the red cell part 1

, : Regulation of hemo globin synthesis during the development of the red cell part 1. New England Journal of Medicine 297(24): 1318-1328

The mature red cell represents the culmination of complex cellular and molecular events by which the primitive stem cell ultimately becomes committed to the highly selective expression of a few genes. In early erythroid cells, globin genes are among the small fraction of DNA sequences that are available for transcription. Most DNA is inaccessible by virtue of its association with histones to form nucleosomes. Nucleosomes may be found on active genes but these structures may then be altered by histone modification or interaction with specific nonhistone chromosomal proteins such that the associated DNA sequences can act as a template for RNA polymerase. Relative rates of degradation, as well as transcriptional and processing events, may contribute to the accumulation of either total globin mRNA or the mRNA's for individual globins. There may be such intrinsic differences in the primary structures of RNA molecules containing .beta. or .DELTA. mRNA sequences that .DELTA. mRNA is relatively less stable and disappears before erythroid maturation is complete.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006288349

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Foulds, L., 1937: A transplantable carcinoma of a domestic fowl, with a discussion of the histogenesis of mixed tumours. A fowl carcinoma, believed to have originated in the oviduct, has been transmitted by cellular grafts. The transplanted tumors had many histo-logical variants, including a spindle form, alveolar car- cinoma; a colloid type and mixed tumors contain...

Ivanov, D.P.; Coyle, B.; Walker, D.A.; Grabowska, A.M., 2016: In vitro models of medulloblastoma: Choosing the right tool for the job. The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice. This review seeks to build...

BRUNER.D.W.; EDWARDS.P.R., 1948: A motile streptococcus from an aborted equine fetus. A streptococcus, sero- logically and biochemically belonging to Lancefield's Group D, was isolated from an aborted equine fetus. It was slightly motile and individual cells were observed to be monotrichous.

Palomeque, M.E.; Ortíz, P.I., 2007: New automatized method with amperometric detection for the determination of azithromycin. A FIA-amperometric method for azithromycin determination was developed. A working glassy carbon electrode and a Ag/AgCl/NaC1 (3 M) reference electrode were used. The determination is based on the electrochemical oxidation of the azithromycin at 0...

Nakae, Y.; Ikeda, K.; Azuma, T.; Hamaguchi, K., 1972: Circular dichroism of hen egg-white lysozyme modified with N-acetylimidazole. Journal of Biochemistry 72(5): 1155-1162

Kurowski, A.; Szarpak, Łukasz.; Bogdański, Łukasz.; Zaśko, P.; Czyżewski, Łukasz., 2015: Comparison of the effectiveness of cardiopulmonary resuscitation with standard manual chest compressions and the use of TrueCPR and PocketCPR feedback devices. High effectiveness of chest compressions is an important element of cardiopulmonary resuscitation (CPR), improving survival and reducing neurological deficits resulting from sudden cardiac arrest. Evaluation of the effectiveness of standard manual...

Mavor, J. W., 1941: General biology. Revised ed. Unknown

ALLISON, A.C., 1956: Sickle-cell anaemia and haemoglobin C. Knowledge of sickle-cell anemia and its related conditions has led to the belief that the main factor for its maintenance in a population in spite of the high death rate among homozygous individuals is due to the resistance possessed by heterozygo...

Sakamoto, S.; Matsueda, S.; Takamori, S.; Toh, U.; Noguchi, M.; Yutani, S.; Yamada, A.; Shichijo, S.; Yamada, T.; Suekane, S.; Kawano, K.; Sasada, T.; Hattori, N.; Kohno, N.; Itoh, K., 2016: Immunological evaluation of peptide vaccination for cancer patients with the HLA-A26 allele. To develop a peptide vaccine for cancer patients with the HLA-A26 allele, which is a minor population worldwide, we investigated the immunological responses of HLA-A26(+) /A26(+) cancer patients to four different CTL epitope peptides under persona...

Barbour Hugh S., 1979: Memorial to George Brown Barbour, 1890-1977. Memorials - Geological Society of America 9: (5 p