EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Regulation of hemo globin synthesis during the development of the red cell part 1


New England Journal of Medicine 297(24): 1318-1328
Regulation of hemo globin synthesis during the development of the red cell part 1
The mature red cell represents the culmination of complex cellular and molecular events by which the primitive stem cell ultimately becomes committed to the highly selective expression of a few genes. In early erythroid cells, globin genes are among the small fraction of DNA sequences that are available for transcription. Most DNA is inaccessible by virtue of its association with histones to form nucleosomes. Nucleosomes may be found on active genes but these structures may then be altered by histone modification or interaction with specific nonhistone chromosomal proteins such that the associated DNA sequences can act as a template for RNA polymerase. Relative rates of degradation, as well as transcriptional and processing events, may contribute to the accumulation of either total globin mRNA or the mRNA's for individual globins. There may be such intrinsic differences in the primary structures of RNA molecules containing .beta. or .DELTA. mRNA sequences that .DELTA. mRNA is relatively less stable and disappears before erythroid maturation is complete.


Accession: 006288349



Related references

Regulation of hemo globin synthesis during the development of the red cell part 3. New England Journal of Medicine 297(26): 1430-1436, 1977

Terminal stages of hemo globin synthesis 2. lack of effect of alpha hemo globin and beta hemo globin chains on the rate of globin synthesis in a human cell free system. Journal of Laboratory and Clinical Medicine 96(5): 871-878, 1980

Studies of the terminal stages of hemo globin synthesis part 1 stimulation of globin chain synthesis by native hemo globin subunits. Blood 53(1): 148-156, 1979

Regulation of hemo globin synthesis in red blood cell development. Federation Proceedings 41(4): ABSTRACT 5940, 1982

Nmr studies of hemo globin part 4 the structure function relationship of human adult hemo globin a and hemo globin chesapeake and its implication to the nature of oxygenation of hemo globin. Biochemical & Biophysical Research Communications 38(4): 779-786, 1970

Elevated hemo globin f associated with an unstable hemo globin hemo globin st etienne hemo globin synthesis in blood erythroid burst forming units in culture. Blood 54(2): 334-343, 1979

Cultured erythroid cells as a model for hemo globin regulation ability of cultured cells to synthesize hemo globin lepore and hemo globin and maintain balanced globin synthesis. Blood 57(5): 873-878, 1981

Differentiation of electrophoretically similar hemo globins such as hemo globin s hemo globin d hemo globin g and hemo globin p or hemo globin a 2 hemo globin c hemo globin e and hemo globin o by electrophoresis of the globin chains. Clinical Chemistry 20(9): 1111-1115, 1974

Epr studies of spin labeled hemo globins part 2 roles of subunit interactions and of intermediate structures in the cooperative oxygenation of hemo globin and the results on hemo globin yakima hemo globin j capetown and carboxy peptidase a and carboxy peptidase b treated hemo globin a. Biochemistry 9(24): 4707-4713, 1970

Micro chromatography of hemo globins part 7 detection of some uncommon hemo globin variants and 2 rapid methods for the quantitation of hemo globin a 2 in the presence of hemo globin c. Journal of Chromatography 143(1): 57-63, 1977