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Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary betaine


, : Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary betaine. Journal of Nutrition 113(3): 519-521

The level of betaine-homocysteine methyltransferase increases in the livers of rats fed diets supplemented with betaine or choline. The increase occurs within 3 days following the change in diet. When betaine was administered by i.p. injection to rats fed choline-free diets, a similar increase within 24 h was observed. Since betaine-homocysteine methyltransferase catalyzes a reaction which is essential for the catabolism of betaine, these changes provide a means for adaptation to excessive levels of dietary choline and betaine.

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