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Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary betaine


, : Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary betaine. Journal of Nutrition 113(3): 519-521

The level of betaine-homocysteine methyltransferase increases in the livers of rats fed diets supplemented with betaine or choline. The increase occurs within 3 days following the change in diet. When betaine was administered by i.p. injection to rats fed choline-free diets, a similar increase within 24 h was observed. Since betaine-homocysteine methyltransferase catalyzes a reaction which is essential for the catabolism of betaine, these changes provide a means for adaptation to excessive levels of dietary choline and betaine.

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Related references

Finkelstein, J.D.; Harris, B.J.; Kyle, W.E.; Martin, J.J., 1982: Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary methionine. The hepatic activity of betaine-homocysteine methyltransferase is a complex function of the content of methionine in the diet. Enzyme levels are lower in the livers of rats fed a 0.3% methionine diet than in livers of animals maintained on either...

Skiba W.E.; Taylor M.P.; Wells M.S.; Mangum J.M.; Awad W.M.Jr, 1982: Purification and characterization of human hepatic betaine homo cysteine s methyl transferase. Federation Proceedings 41(3): ABSTRACT 2748

Balinska, M.; Paszewski, A., 1979: Betaine homo cysteine methyl transferase ec 2.1.1.5 in the fungus aspergillus nidulans. A betaine:homocysteine methyltransferase activity was seen in the cell-free extracts from the fungus A. nidulans. Among methionine-requiring mutants which do not grow on homocysteine, one class responds to betaine, indicating that this compound ca...

Grzelakowska-Sztabert, B.; Balinska, M., 1980: Induction of betaine homo cysteine methyl transferase ec 2.1.1.5 in some murine cells cultured in vitro. Betaine when present in the culture medium could induce the activity of betaine:homocysteine methyltransferase (EC 2.1.1.5) in mouse L-cells, leukemic L1210 cells, and mouse embryo fibroblasts grown in vitro. This process was time- and concentrati...

Finkelstein J.D.; Martin J.J., 1982: Regulation of hepatic betaine by homo cysteine. Clinical Research 30(2): 391A

Sauer, H.; Howell, J.N.; Jaenicke, L., 1973: Importance and regulation of cobalamin dependent methionine synthetase and betaine homo cysteine methyl transferase in methionine and tetra hydro folic acid metabolism of the rat. Research in Experimental Medicine 160(3): 171-180

Karelin, A.A.; Bikmetov, M.S.; Nikolaev, A.Y., 1977: The stimulating effect of glucagon and theophylline on the activity of betaine homo cysteine methyl transferase the role of cyclic amp. Effect of glucagon, theophylline, NaF and cyclic[c]AMP on the activity of betaine-homocysteine-methyl transferase (BHMT) was studied in homogenates of rat liver tissue. I.p. administration of theophylline into adult rats increased the BHMT activit...

Saarinen, M.T.; Kettunen, H.; Pulliainen, K.; Peuranen, S.; Tiihonen, K.; Remus, J., 2001: A novel method to analyze betaine in chicken liver: effect of dietary betaine and choline supplementation on the hepatic betaine concentration in broiler chicks. Betaine was measured from liver tissue by a high-performance liquid chromatographic (HPLC) method developed for this study. The method involves homogenization of liver in acetate buffer at pH 6 and precipitation of protein with trichloroacetic aci...

Finkelstein, J.D.; Martin, J.J.; Harris, B.J.; Kyle, W.E., 1983: Regulation of hepatic betaine-homocysteine methyltransferase by dietary betaine. The level of betaine-homocysteine methyltransferase increases in the livers of rats fed on diets supplemented with betaine or choline. The increase occurs within 3 days after the change in diet. When betaine was given intraperitoneally to rats fed...

Finkelstein, J.D.; Martin, J.J., 1984: Inactivation of betaine homo cysteine methyl transferase ec 2.1.1.5 by adenosyl methionine and adenosyl ethionine. Preincubation of betaine-homocysteine methyltransferase, prepared from rat liver, with either S-adenosylmethionine or S-adenosylethionine results in a marked loss of enzyme activity. Gel filtration did not restore activity. However both S-adenosyl...