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Regulation of hepatic betaine homo cysteine methyl transferase ec by dietary methionine

, : Regulation of hepatic betaine homo cysteine methyl transferase ec by dietary methionine. Biochemical and Biophysical Research Communications 108(1): 344-348

The hepatic activity of betaine-homocysteine methyltransferase is a complex function of the content of methionine in the diet. Enzyme levels are lower in the livers of rats fed a 0.3% methionine diet than in livers of animals maintained on either methionine-free or excessive methionine (1.0%) rations. Because activities are increased at both extremes of the spectrum of dietary methionine intake, the betaine-homocysteine methyltransferase reaction may function both to maintian tissue concentrations of methionine when intake of this amino acid is limited and to remove homocysteine when methionine intake is excessive.

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