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Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary methionine


, : Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary methionine. Biochemical and Biophysical Research Communications 108(1): 344-348

The hepatic activity of betaine-homocysteine methyltransferase is a complex function of the content of methionine in the diet. Enzyme levels are lower in the livers of rats fed a 0.3% methionine diet than in livers of animals maintained on either methionine-free or excessive methionine (1.0%) rations. Because activities are increased at both extremes of the spectrum of dietary methionine intake, the betaine-homocysteine methyltransferase reaction may function both to maintian tissue concentrations of methionine when intake of this amino acid is limited and to remove homocysteine when methionine intake is excessive.

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Finkelstein, J.D.; Martin, J.J.; Harris, B.J.; Kyle, W.E., 1983: Regulation of hepatic betaine homo cysteine methyl transferase ec 2.1.1.5 by dietary betaine. The level of betaine-homocysteine methyltransferase increases in the livers of rats fed diets supplemented with betaine or choline. The increase occurs within 3 days following the change in diet. When betaine was administered by i.p. injection to...

Sauer, H.; Howell, J.N.; Jaenicke, L., 1973: Importance and regulation of cobalamin dependent methionine synthetase and betaine homo cysteine methyl transferase in methionine and tetra hydro folic acid metabolism of the rat. Research in Experimental Medicine 160(3): 171-180

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Tautt, J.W.; Anuszewska, E.L.; Koziorowska, J.H., 1982: Methionine regulation of n 5 methyl tetra hydro folate homo cysteine methyl transferase ec 2.1.1.5 and its influence on the growth and protein synthesis in normal neoplastic and transformed cells in culture. Normal human embryonic fibroblasts (CLV-58) and normal embryonic rat fibroblasts (REF) revealed equal growth in media containing 0.2 mM DL-homocysteine thiolactone (HOM) or in methionine (METH) enriched with 1.5 .mu.M cyanocobalamin and 0.1 mM fol...

Kamely, D.; Littlefield, J.W.; Erbe, R.W., 1973: Regulation of 5 methyl tetra hydro folate homo cysteine methyl transferase activity by methionine vitamin b 12 and folate in cultured baby hamster kidney cells. Proceedings of the National Academy of Sciences of the United States of America 70(9): 2585-2589

Balinska, M.; Paszewski, A., 1979: Betaine homo cysteine methyl transferase ec 2.1.1.5 in the fungus aspergillus nidulans. A betaine:homocysteine methyltransferase activity was seen in the cell-free extracts from the fungus A. nidulans. Among methionine-requiring mutants which do not grow on homocysteine, one class responds to betaine, indicating that this compound ca...

Grzelakowska-Sztabert, B.; Balinska, M., 1980: Induction of betaine homo cysteine methyl transferase ec 2.1.1.5 in some murine cells cultured in vitro. Betaine when present in the culture medium could induce the activity of betaine:homocysteine methyltransferase (EC 2.1.1.5) in mouse L-cells, leukemic L1210 cells, and mouse embryo fibroblasts grown in vitro. This process was time- and concentrati...

Bryan J.E.; Allamong B.D., 1976: Purification of s methyl l methionine homo cysteine methyl transferase in triticum aestivum gramineae. Proceedings of the Indiana Academy of Science (86): 141