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Regulation of hepatic cholesterol biosynthesis by clofibrate administration


, : Regulation of hepatic cholesterol biosynthesis by clofibrate administration. Journal of Pharmacology and Experimental Therapeutics 178(2): 361-370


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Rousselet, F.; Fredj, G.; Clenet, M., 1986: Comparative study of clofibrate and tiadenol on cholesterol metabolism in rat and hamster i. comparative effects of clofibrate and tiadenol on cholesterol hepatic and intestinal biosynthesis in hamster and rat. Hepatic biosynthesis of cholesterol from acetate-214C was decreased in the rat and golden hamster under the effects of treatment with two hypolipidemic agents completely different from a chemical standpoint:clofibrate and tiadenol. There was also...

Cayen M.N.; Dvornik D., 1970: Effect of combined administration of clofibrate and cholestyramine on cholesterol biosynthesis in the rat. Circulation Research Supplement 42(4-3): III-14

Rousselet, F.; Fredj, G.; Clenet, M., 1986: Comparative effects of clofibrate and tiadenol on the metabolism of cholesterol in rats and hamsters. I. Comparative action of clofibrate and tiadenol on hepatic and intestinal biosynthesis of cholesterol in hamsters and rats. Annales Pharmaceutiques Francaises 44(4): 269-276

Darakjian V.N.; Arslanian M.J.; Khachadurian A.K., 1972: Regulation of hepatic cholesterol biosynthesis by dietary cholesterol isolation of a mitochondrial inhibitor. Pediatric Research 6(4): 397

Shibata, N.; Jishage, K-ichi.; Arita, M.; Watanabe, M.; Kawase, Y.; Nishikawa, K.; Natori, Y.; Inoue, H.; Shimano, H.; Yamada, N.; Tsujimoto, M.; Arai, H., 2006: Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. Supernatant protein factor (SPF) is a novel cholesterol biosynthesis- accelerating protein expressed in liver and small intestine. Here, we report on the physiological role of SPF by using Spf-deficient mice. Although plasma cholesterol levels we...

Turley, S.D.; Dietschy, J.M., 1979: Regulation of biliary cholesterol output in the rat: dissociation from the rate of hepatic cholesterol synthesis, the size of the hepatic cholesteryl ester pool, and the hepatic uptake of chylomicron cholesterol. These studies were designed to determine the importance of the rate of hepatic cholesterol synthesis, the size of the hepatic cholesteryl ester pool, the amount of chylomicron cholesterol reaching the liver, and the rate of bile acid transport int...

Wu, N.; Sarna, L.K.; Siow, Y.L.; O.K., 2011: Regulation of hepatic cholesterol biosynthesis by berberine during hyperhomocysteinemia. Hyperhomocysteinemia, an elevation of blood homocysteine levels, is a metabolic disorder associated with dysfunction of multiple organs. We previously demonstrated that hyperhomocysteinemia stimulated hepatic 3-hydroxy-3-methylglutaryl coenzyme A...

Calandra, S.; Guariento, D.; Rivasi, F., 1973: Regulation of cholesterol biosynthesis in rat liver after the administration of N-2-fluorenylacetamide. Laboratory Investigation; A Journal of Technical Methods and Pathology 28(6): 723-727

Kang, M.K.; Kim, C.K.; Johng, T.N.; Paik, Y.K., 1995: Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 8-isomerase. The membrane bound sterol-8-isomerase (isomerase) catalyzes the anaerobic conversion of sterol-8-ene to the sterol-7-ene isomer in eucaryotes. To examine the regulatory mechanism as well as molecular characteristics of the isomerase we investigate...

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